Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects

RAS mutations prevalent in high-risk leukemia have been linked to relapse and chemotherapy resistance. Efforts to directly target RAS proteins have been largely unsuccessful. However, since RAS-mediated transformation is dependent on signaling through the RAS-related C3 botulinum toxin substrate (RA...

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Detalles Bibliográficos
Autores principales: Canovas Nunes, Sara, De Vita, Serena, Anighoro, Andrew, Autelitano, François, Beaumont, Edward, Klingbeil, Pamela, McGuinness, Meaghan, Duvert, Beatrice, Harris, Chad, Yang, Lu, Pokharel, Sheela Pangeni, Chen, Chun-Wei, Ermann, Monika, Williams, David A., Xu, Haiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010429/
https://www.ncbi.nlm.nih.gov/pubmed/35422065
http://dx.doi.org/10.1038/s41408-022-00663-z

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