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Inactivation of various variant types of SARS-CoV-2 by indoor-light-sensitive TiO(2)-based photocatalyst

Photocatalysts are promising materials for solid-state antiviral coatings to protect against the spread of pandemic coronavirus disease (COVID-19). This paper reports that copper oxide nanoclusters grafted with titanium dioxide (Cu(x)O/TiO(2)) inactivated the severe acute respiratory syndrome corona...

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Detalles Bibliográficos
Autores principales: Nakano, Ryuichi, Yamaguchi, Akira, Sunada, Kayano, Nagai, Takeshi, Nakano, Akiyo, Suzuki, Yuki, Yano, Hisakazu, Ishiguro, Hitoshi, Miyauchi, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010443/
https://www.ncbi.nlm.nih.gov/pubmed/35422456
http://dx.doi.org/10.1038/s41598-022-09402-7
Descripción
Sumario:Photocatalysts are promising materials for solid-state antiviral coatings to protect against the spread of pandemic coronavirus disease (COVID-19). This paper reports that copper oxide nanoclusters grafted with titanium dioxide (Cu(x)O/TiO(2)) inactivated the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, including its Delta variant, even under dark condition, and further inactivated it under illumination with a white fluorescent bulb. To investigate its inactivation mechanism, the denaturation of spike proteins of SARS-CoV-2 was examined by sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS-PAGE) and enzyme-linked immunosorbent assay (ELISA). In addition to spike proteins, fragmentation of ribonucleic acids in SARS-CoV-2 was investigated by real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR). As a result, both spike proteins and RNAs in the SARS-CoV-2 virus were damaged by the Cu(x)O/TiO(2) photocatalyst even under dark condition and were further damaged under white fluorescent bulb illumination. Based on the present antiviral mechanism, the Cu(x)O/TiO(2) photocatalyst will be effective in inactivating other potential mutant strains of SARS-CoV-2. The Cu(x)O/TiO(2) photocatalyst can thus be used to reduce the infectious risk of COVID-19 in an indoor environment, where light illumination is turned on during the day and off during the night.