Glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular Castleman disease-like features

We report a case of mantle cell lymphoma mimicking Castleman disease. A 76-year-old man presented with generalized lymphadenopathy, splenomegaly, anemia, polyclonal gammopathy, and pulmonary infiltrations. Lymph node biopsy revealed histological features of hyaline vascular Castleman disease. Treatm...

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Autores principales: Togitani, Kazuto, Iguchi, Mitsuko, Asagiri, Tadashi, Ogasawara, Fumiya, Murakami, Ichiro, Kojima, Kensuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JSLRT 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010492/
https://www.ncbi.nlm.nih.gov/pubmed/34707036
http://dx.doi.org/10.3960/jslrt.21024
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author Togitani, Kazuto
Iguchi, Mitsuko
Asagiri, Tadashi
Ogasawara, Fumiya
Murakami, Ichiro
Kojima, Kensuke
author_facet Togitani, Kazuto
Iguchi, Mitsuko
Asagiri, Tadashi
Ogasawara, Fumiya
Murakami, Ichiro
Kojima, Kensuke
author_sort Togitani, Kazuto
collection PubMed
description We report a case of mantle cell lymphoma mimicking Castleman disease. A 76-year-old man presented with generalized lymphadenopathy, splenomegaly, anemia, polyclonal gammopathy, and pulmonary infiltrations. Lymph node biopsy revealed histological features of hyaline vascular Castleman disease. Treatment with prednisolone induced lymphocytosis with immunophenotypic and genetic features of mantle cell lymphoma. A detailed immunohistochemical study of the lymph node demonstrated a mantle cell lymphoma-mantle zone growth pattern. Glucocorticoid-induced distribution lymphocytosis has not been reported in mantle cell lymphoma. Careful observation of circulating lymphocytes during steroid treatment may enable diagnosis of the underlying occult lymphoma in a subset of patients exhibiting clinical manifestations of Castleman disease.
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spelling pubmed-90104922022-05-04 Glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular Castleman disease-like features Togitani, Kazuto Iguchi, Mitsuko Asagiri, Tadashi Ogasawara, Fumiya Murakami, Ichiro Kojima, Kensuke J Clin Exp Hematop Case Report We report a case of mantle cell lymphoma mimicking Castleman disease. A 76-year-old man presented with generalized lymphadenopathy, splenomegaly, anemia, polyclonal gammopathy, and pulmonary infiltrations. Lymph node biopsy revealed histological features of hyaline vascular Castleman disease. Treatment with prednisolone induced lymphocytosis with immunophenotypic and genetic features of mantle cell lymphoma. A detailed immunohistochemical study of the lymph node demonstrated a mantle cell lymphoma-mantle zone growth pattern. Glucocorticoid-induced distribution lymphocytosis has not been reported in mantle cell lymphoma. Careful observation of circulating lymphocytes during steroid treatment may enable diagnosis of the underlying occult lymphoma in a subset of patients exhibiting clinical manifestations of Castleman disease. JSLRT 2021-10-26 /pmc/articles/PMC9010492/ /pubmed/34707036 http://dx.doi.org/10.3960/jslrt.21024 Text en © 2021 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License.
spellingShingle Case Report
Togitani, Kazuto
Iguchi, Mitsuko
Asagiri, Tadashi
Ogasawara, Fumiya
Murakami, Ichiro
Kojima, Kensuke
Glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular Castleman disease-like features
title Glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular Castleman disease-like features
title_full Glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular Castleman disease-like features
title_fullStr Glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular Castleman disease-like features
title_full_unstemmed Glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular Castleman disease-like features
title_short Glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular Castleman disease-like features
title_sort glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular castleman disease-like features
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010492/
https://www.ncbi.nlm.nih.gov/pubmed/34707036
http://dx.doi.org/10.3960/jslrt.21024
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