Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature

Marginal zone lymphoma (MZL) arising from the anterior mediastinum is rare. In the majority of reported cases, the tumor was incidentally discovered, reflecting its indolent clinical features. We present a 38-year-old woman who had no medical history, and presented with a bulky anterior mediastinal...

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Autores principales: Kitamura, Wataru, Asada, Noboru, Tabata, Tetsuya, Shibata, Rei, Nishi, Tatsuya, Kato, Yuka, Takasuka, Hiroki, Fujiwara, Hideaki, Ennishi, Daisuke, Nishimori, Hisakazu, Fujii, Nobuharu, Matsuoka, Ken-ichi, Kiura, Katsuyuki, Yoshino, Tadashi, Maeda, Yoshinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JSLRT 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010493/
https://www.ncbi.nlm.nih.gov/pubmed/34840205
http://dx.doi.org/10.3960/jslrt.21010
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author Kitamura, Wataru
Asada, Noboru
Tabata, Tetsuya
Shibata, Rei
Nishi, Tatsuya
Kato, Yuka
Takasuka, Hiroki
Fujiwara, Hideaki
Ennishi, Daisuke
Nishimori, Hisakazu
Fujii, Nobuharu
Matsuoka, Ken-ichi
Kiura, Katsuyuki
Yoshino, Tadashi
Maeda, Yoshinobu
author_facet Kitamura, Wataru
Asada, Noboru
Tabata, Tetsuya
Shibata, Rei
Nishi, Tatsuya
Kato, Yuka
Takasuka, Hiroki
Fujiwara, Hideaki
Ennishi, Daisuke
Nishimori, Hisakazu
Fujii, Nobuharu
Matsuoka, Ken-ichi
Kiura, Katsuyuki
Yoshino, Tadashi
Maeda, Yoshinobu
author_sort Kitamura, Wataru
collection PubMed
description Marginal zone lymphoma (MZL) arising from the anterior mediastinum is rare. In the majority of reported cases, the tumor was incidentally discovered, reflecting its indolent clinical features. We present a 38-year-old woman who had no medical history, and presented with a bulky anterior mediastinal tumor complicated by life-threatening compression of the vasculature and bronchi. Biopsy specimens of the neoplasm suggested transformed diffuse large B-cell lymphoma (DLBCL) from MZL. To our best knowledge, this is the first case report of anterior mediastinum MZL associated with an aggressive clinical course and life-threatening complications likely due to transformation to DLBCL.
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spelling pubmed-90104932022-05-04 Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature Kitamura, Wataru Asada, Noboru Tabata, Tetsuya Shibata, Rei Nishi, Tatsuya Kato, Yuka Takasuka, Hiroki Fujiwara, Hideaki Ennishi, Daisuke Nishimori, Hisakazu Fujii, Nobuharu Matsuoka, Ken-ichi Kiura, Katsuyuki Yoshino, Tadashi Maeda, Yoshinobu J Clin Exp Hematop Case Report Marginal zone lymphoma (MZL) arising from the anterior mediastinum is rare. In the majority of reported cases, the tumor was incidentally discovered, reflecting its indolent clinical features. We present a 38-year-old woman who had no medical history, and presented with a bulky anterior mediastinal tumor complicated by life-threatening compression of the vasculature and bronchi. Biopsy specimens of the neoplasm suggested transformed diffuse large B-cell lymphoma (DLBCL) from MZL. To our best knowledge, this is the first case report of anterior mediastinum MZL associated with an aggressive clinical course and life-threatening complications likely due to transformation to DLBCL. JSLRT 2021-11-26 /pmc/articles/PMC9010493/ /pubmed/34840205 http://dx.doi.org/10.3960/jslrt.21010 Text en © 2021 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License.
spellingShingle Case Report
Kitamura, Wataru
Asada, Noboru
Tabata, Tetsuya
Shibata, Rei
Nishi, Tatsuya
Kato, Yuka
Takasuka, Hiroki
Fujiwara, Hideaki
Ennishi, Daisuke
Nishimori, Hisakazu
Fujii, Nobuharu
Matsuoka, Ken-ichi
Kiura, Katsuyuki
Yoshino, Tadashi
Maeda, Yoshinobu
Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature
title Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature
title_full Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature
title_fullStr Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature
title_full_unstemmed Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature
title_short Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature
title_sort transformed diffuse large b-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010493/
https://www.ncbi.nlm.nih.gov/pubmed/34840205
http://dx.doi.org/10.3960/jslrt.21010
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