Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism

Impressive achievements in clinical trials to treat hemophilia establish a milestone in the development of gene therapy. It highlights the significance of AAV-mediated gene delivery to liver. AAV5 is a unique serotype featured by low neutralizing antibody prevalence. Nevertheless, its liver infectiv...

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Detalles Bibliográficos
Autores principales: Wang, Yuqiu, Yang, Chen, Hu, Hanyang, Chen, Chen, Yan, Mengdi, Ling, Feixiang, Wang, Kathy Cheng, Wang, Xintao, Deng, Zhe, Zhou, Xinyue, Zhang, Feixu, Lin, Sen, Du, Zengmin, Zhao, Kai, Xiao, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010518/
https://www.ncbi.nlm.nih.gov/pubmed/35474733
http://dx.doi.org/10.1016/j.omtn.2022.03.017

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