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3D-Printed Hydrogels in Orthopedics: Developments, Limitations, and Perspectives

Three-dimensional (3D) printing has been used in medical research and practice for several years. Various aspects can affect the finished product of 3D printing, and it has been observed that the impact of the raw materials used for 3D printing is unique. Currently, hydrogels, including various natu...

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Autores principales: Liu, Zhen, Xin, Weiwei, Ji, Jindou, Xu, Jialian, Zheng, Liangjun, Qu, Xinhua, Yue, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010546/
https://www.ncbi.nlm.nih.gov/pubmed/35433662
http://dx.doi.org/10.3389/fbioe.2022.845342
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author Liu, Zhen
Xin, Weiwei
Ji, Jindou
Xu, Jialian
Zheng, Liangjun
Qu, Xinhua
Yue, Bing
author_facet Liu, Zhen
Xin, Weiwei
Ji, Jindou
Xu, Jialian
Zheng, Liangjun
Qu, Xinhua
Yue, Bing
author_sort Liu, Zhen
collection PubMed
description Three-dimensional (3D) printing has been used in medical research and practice for several years. Various aspects can affect the finished product of 3D printing, and it has been observed that the impact of the raw materials used for 3D printing is unique. Currently, hydrogels, including various natural and synthetic materials, are the most biologically and physically advantageous biological raw materials, and their use in orthopedics has increased considerably in recent years. 3D-printed hydrogels can be used in the construction of extracellular matrix during 3D printing processes. In addition to providing sufficient space structure for osteogenesis and chondrogenesis, hydrogels have shown positive effects on osteogenic and chondrogenic signaling pathways, promoting tissue repair in various dimensions. 3D-printed hydrogels are currently attracting extensive attention for the treatment of bone and joint injuries owing to the above-mentioned significant advantages. Furthermore, hydrogels have been recently used in infection prevention because of their antiseptic impact during the perioperative period. However, there are a few shortcomings associated with hydrogels including difficulty in getting rid of the constraints of the frame, poor mechanical strength, and burst release of loadings. These drawbacks could be overcome by combining 3D printing technology and novel hydrogel material through a multi-disciplinary approach. In this review, we provide a brief description and summary of the unique advantages of 3D printing technology in the field of orthopedics. In addition, some 3D printable hydrogels possessing prominent features, along with the key scope for their applications in bone joint repair, reconstruction, and antibacterial performance, are discussed to highlight the considerable prospects of hydrogels in the field of orthopedics.
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spelling pubmed-90105462022-04-16 3D-Printed Hydrogels in Orthopedics: Developments, Limitations, and Perspectives Liu, Zhen Xin, Weiwei Ji, Jindou Xu, Jialian Zheng, Liangjun Qu, Xinhua Yue, Bing Front Bioeng Biotechnol Bioengineering and Biotechnology Three-dimensional (3D) printing has been used in medical research and practice for several years. Various aspects can affect the finished product of 3D printing, and it has been observed that the impact of the raw materials used for 3D printing is unique. Currently, hydrogels, including various natural and synthetic materials, are the most biologically and physically advantageous biological raw materials, and their use in orthopedics has increased considerably in recent years. 3D-printed hydrogels can be used in the construction of extracellular matrix during 3D printing processes. In addition to providing sufficient space structure for osteogenesis and chondrogenesis, hydrogels have shown positive effects on osteogenic and chondrogenic signaling pathways, promoting tissue repair in various dimensions. 3D-printed hydrogels are currently attracting extensive attention for the treatment of bone and joint injuries owing to the above-mentioned significant advantages. Furthermore, hydrogels have been recently used in infection prevention because of their antiseptic impact during the perioperative period. However, there are a few shortcomings associated with hydrogels including difficulty in getting rid of the constraints of the frame, poor mechanical strength, and burst release of loadings. These drawbacks could be overcome by combining 3D printing technology and novel hydrogel material through a multi-disciplinary approach. In this review, we provide a brief description and summary of the unique advantages of 3D printing technology in the field of orthopedics. In addition, some 3D printable hydrogels possessing prominent features, along with the key scope for their applications in bone joint repair, reconstruction, and antibacterial performance, are discussed to highlight the considerable prospects of hydrogels in the field of orthopedics. Frontiers Media S.A. 2022-04-01 /pmc/articles/PMC9010546/ /pubmed/35433662 http://dx.doi.org/10.3389/fbioe.2022.845342 Text en Copyright © 2022 Liu, Xin, Ji, Xu, Zheng, Qu and Yue. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Liu, Zhen
Xin, Weiwei
Ji, Jindou
Xu, Jialian
Zheng, Liangjun
Qu, Xinhua
Yue, Bing
3D-Printed Hydrogels in Orthopedics: Developments, Limitations, and Perspectives
title 3D-Printed Hydrogels in Orthopedics: Developments, Limitations, and Perspectives
title_full 3D-Printed Hydrogels in Orthopedics: Developments, Limitations, and Perspectives
title_fullStr 3D-Printed Hydrogels in Orthopedics: Developments, Limitations, and Perspectives
title_full_unstemmed 3D-Printed Hydrogels in Orthopedics: Developments, Limitations, and Perspectives
title_short 3D-Printed Hydrogels in Orthopedics: Developments, Limitations, and Perspectives
title_sort 3d-printed hydrogels in orthopedics: developments, limitations, and perspectives
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010546/
https://www.ncbi.nlm.nih.gov/pubmed/35433662
http://dx.doi.org/10.3389/fbioe.2022.845342
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