Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks

Hyperthermia inhibits DNA double-strand break (DSB) repair that utilizes homologous recombination (HR) pathway by a poorly defined mechanism(s); however, the mechanisms for this inhibition remain unclear. Here we report that hyperthermia decreases H4K16 acetylation (H4K16ac), an epigenetic modificat...

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Detalles Bibliográficos
Autores principales: Chakraborty, Sharmistha, Singh, Mayank, Pandita, Raj K., Singh, Vipin, Lo, Calvin S.C., Leonard, Fransisca, Horikoshi, Nobuo, Moros, Eduardo G., Guha, Deblina, Hunt, Clayton R., Chau, Eric, Ahmed, Kazi M., Sethi, Prayas, Charaka, Vijaya, Godin, Biana, Makhijani, Kalpana, Scherthan, Harry, Deck, Jeanette, Hausmann, Michael, Mushtaq, Arjamand, Altaf, Mohammad, Ramos, Kenneth S., Bhat, Krishna M., Taneja, Nitika, Das, Chandrima, Pandita, Tej K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010620/
https://www.ncbi.nlm.nih.gov/pubmed/35434547
http://dx.doi.org/10.1016/j.isci.2022.104142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010620/
https://www.ncbi.nlm.nih.gov/pubmed/35434547
http://dx.doi.org/10.1016/j.isci.2022.104142

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