De Novo KRAS G12C–Mutant SCLC: A Case Report

The application of KRAS G12C inhibitors in the setting of NSCLC represents a major milestone for a previously “undruggable” target. Here, we present the second reported case of de novo KRAS G12C–mutant primary SCLC. Would our patient benefit from a KRAS G12C inhibitor?

Detalles Bibliográficos
Autores principales: Balbach, Meridith L., Eisenberg, Rosana, Iams, Wade T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010630/
https://www.ncbi.nlm.nih.gov/pubmed/35434667
http://dx.doi.org/10.1016/j.jtocrr.2022.100306
_version_ 1784687521222885376
author Balbach, Meridith L.
Eisenberg, Rosana
Iams, Wade T.
author_facet Balbach, Meridith L.
Eisenberg, Rosana
Iams, Wade T.
author_sort Balbach, Meridith L.
collection PubMed
description The application of KRAS G12C inhibitors in the setting of NSCLC represents a major milestone for a previously “undruggable” target. Here, we present the second reported case of de novo KRAS G12C–mutant primary SCLC. Would our patient benefit from a KRAS G12C inhibitor?
format Online
Article
Text
id pubmed-9010630
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-90106302022-04-16 De Novo KRAS G12C–Mutant SCLC: A Case Report Balbach, Meridith L. Eisenberg, Rosana Iams, Wade T. JTO Clin Res Rep Case Report The application of KRAS G12C inhibitors in the setting of NSCLC represents a major milestone for a previously “undruggable” target. Here, we present the second reported case of de novo KRAS G12C–mutant primary SCLC. Would our patient benefit from a KRAS G12C inhibitor? Elsevier 2022-03-19 /pmc/articles/PMC9010630/ /pubmed/35434667 http://dx.doi.org/10.1016/j.jtocrr.2022.100306 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Balbach, Meridith L.
Eisenberg, Rosana
Iams, Wade T.
De Novo KRAS G12C–Mutant SCLC: A Case Report
title De Novo KRAS G12C–Mutant SCLC: A Case Report
title_full De Novo KRAS G12C–Mutant SCLC: A Case Report
title_fullStr De Novo KRAS G12C–Mutant SCLC: A Case Report
title_full_unstemmed De Novo KRAS G12C–Mutant SCLC: A Case Report
title_short De Novo KRAS G12C–Mutant SCLC: A Case Report
title_sort de novo kras g12c–mutant sclc: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010630/
https://www.ncbi.nlm.nih.gov/pubmed/35434667
http://dx.doi.org/10.1016/j.jtocrr.2022.100306
work_keys_str_mv AT balbachmeridithl denovokrasg12cmutantsclcacasereport
AT eisenbergrosana denovokrasg12cmutantsclcacasereport
AT iamswadet denovokrasg12cmutantsclcacasereport

Ejemplares similares