Cingulin binds to the ZU5 domain of scaffolding protein ZO-1 to promote its extended conformation, stabilization, and tight junction accumulation

Zonula occludens-1 (ZO-1), the major scaffolding protein of tight junctions (TJs), recruits the cytoskeleton-associated proteins cingulin (CGN) and paracingulin (CGNL1) to TJs by binding to their N-terminal ZO-1 interaction motif. The conformation of ZO-1 can be either folded or extended, depending...

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Detalles Bibliográficos
Autores principales: Vasileva, Ekaterina, Spadaro, Domenica, Rouaud, Florian, King, Jonathan M., Flinois, Arielle, Shah, Jimit, Sluysmans, Sophie, Méan, Isabelle, Jond, Lionel, Turner, Jerrold R., Citi, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010756/
https://www.ncbi.nlm.nih.gov/pubmed/35259394
http://dx.doi.org/10.1016/j.jbc.2022.101797

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