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Multiubiquitination of TRPV4 reduces channel activity independent of surface localization

Ubiquitin (Ub)-mediated regulation of plasmalemmal ion channel activity canonically occurs via stimulation of endocytosis. Whether ubiquitination can modulate channel activity by alternative mechanisms remains unknown. Here, we show that the transient receptor potential vanilloid 4 (TRPV4) cation ch...

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Detalles Bibliográficos
Autores principales:	Aisenberg, William H., McCray, Brett A., Sullivan, Jeremy M., Diehl, Erika, DeVine, Lauren R., Alevy, Jonathan, Bagnell, Anna M., Carr, Patrice, Donohue, Jack K., Goretzki, Benedikt, Cole, Robert N., Hellmich, Ute A., Sumner, Charlotte J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010760/ https://www.ncbi.nlm.nih.gov/pubmed/35300980 http://dx.doi.org/10.1016/j.jbc.2022.101826

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