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Practical Considerations for Use of Direct Oral Anticoagulants in Children
Direct oral anticoagulants (DOACs) provide an attractive alternative for the management and prevention of thrombosis in pediatric patients. With multiple ongoing and published pediatric trials and recent regulatory approval of dabigatran and rivaroxaban, the landscape of pediatric anticoagulation is...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010784/ https://www.ncbi.nlm.nih.gov/pubmed/35433559 http://dx.doi.org/10.3389/fped.2022.860369 |
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author | Whitworth, Hilary Raffini, Leslie |
author_facet | Whitworth, Hilary Raffini, Leslie |
author_sort | Whitworth, Hilary |
collection | PubMed |
description | Direct oral anticoagulants (DOACs) provide an attractive alternative for the management and prevention of thrombosis in pediatric patients. With multiple ongoing and published pediatric trials and recent regulatory approval of dabigatran and rivaroxaban, the landscape of pediatric anticoagulation is rapidly changing. However, as pediatricians gain experience with these drugs, it is important to be mindful of pediatric-specific considerations that may limit the use of DOACs in certain children and adolescents. While there is increasing adult data and experience, there is a paucity of real-world evidence to guide the use of these drugs in children who would not have met clinical trial inclusion criteria. In this mini review, we summarize pediatric specific data, areas for future research, and practical considerations for the use of DOACs in children and adolescents. |
format | Online Article Text |
id | pubmed-9010784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90107842022-04-16 Practical Considerations for Use of Direct Oral Anticoagulants in Children Whitworth, Hilary Raffini, Leslie Front Pediatr Pediatrics Direct oral anticoagulants (DOACs) provide an attractive alternative for the management and prevention of thrombosis in pediatric patients. With multiple ongoing and published pediatric trials and recent regulatory approval of dabigatran and rivaroxaban, the landscape of pediatric anticoagulation is rapidly changing. However, as pediatricians gain experience with these drugs, it is important to be mindful of pediatric-specific considerations that may limit the use of DOACs in certain children and adolescents. While there is increasing adult data and experience, there is a paucity of real-world evidence to guide the use of these drugs in children who would not have met clinical trial inclusion criteria. In this mini review, we summarize pediatric specific data, areas for future research, and practical considerations for the use of DOACs in children and adolescents. Frontiers Media S.A. 2022-04-01 /pmc/articles/PMC9010784/ /pubmed/35433559 http://dx.doi.org/10.3389/fped.2022.860369 Text en Copyright © 2022 Whitworth and Raffini. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Whitworth, Hilary Raffini, Leslie Practical Considerations for Use of Direct Oral Anticoagulants in Children |
title | Practical Considerations for Use of Direct Oral Anticoagulants in Children |
title_full | Practical Considerations for Use of Direct Oral Anticoagulants in Children |
title_fullStr | Practical Considerations for Use of Direct Oral Anticoagulants in Children |
title_full_unstemmed | Practical Considerations for Use of Direct Oral Anticoagulants in Children |
title_short | Practical Considerations for Use of Direct Oral Anticoagulants in Children |
title_sort | practical considerations for use of direct oral anticoagulants in children |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010784/ https://www.ncbi.nlm.nih.gov/pubmed/35433559 http://dx.doi.org/10.3389/fped.2022.860369 |
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