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Case Report: Using basic liver function tests as a guide to suspected Wilson’s disease
We present a case of a 36-year-old female patient who presented with subacute liver disease with a history of alcohol abuse. On basic liver function tests (LFT), she had aspartate transaminase / alanine transaminase > 2.2 and alkaline phosphatase / total bilirubin < 4. This pattern in acute li...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010801/ https://www.ncbi.nlm.nih.gov/pubmed/35475033 http://dx.doi.org/10.12688/f1000research.54569.2 |
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author | Adhikari, Sudeep Shah, Prashant Kumar Sharma, Yuba Raj |
author_facet | Adhikari, Sudeep Shah, Prashant Kumar Sharma, Yuba Raj |
author_sort | Adhikari, Sudeep |
collection | PubMed |
description | We present a case of a 36-year-old female patient who presented with subacute liver disease with a history of alcohol abuse. On basic liver function tests (LFT), she had aspartate transaminase / alanine transaminase > 2.2 and alkaline phosphatase / total bilirubin < 4. This pattern in acute liver failure patients signifies Wilson’s disease. Its presence in our patient with subacute liver disease also prompted us to suspect Wilson’s disease and we extended the liver disease screen to include slit lamp eye examination for Kayser-Fleischer rings, serum ceruloplasmin and 24-hour urinary copper level, which led to the diagnosis. She improved clinically and biochemically with zinc acetate therapy. As screening for rare diseases is not always possible in low-income countries, this case demonstrates the usefulness of the basic LFT as a guide for suspecting Wilson’s disease in patients with liver disease. |
format | Online Article Text |
id | pubmed-9010801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-90108012022-04-25 Case Report: Using basic liver function tests as a guide to suspected Wilson’s disease Adhikari, Sudeep Shah, Prashant Kumar Sharma, Yuba Raj F1000Res Case Report We present a case of a 36-year-old female patient who presented with subacute liver disease with a history of alcohol abuse. On basic liver function tests (LFT), she had aspartate transaminase / alanine transaminase > 2.2 and alkaline phosphatase / total bilirubin < 4. This pattern in acute liver failure patients signifies Wilson’s disease. Its presence in our patient with subacute liver disease also prompted us to suspect Wilson’s disease and we extended the liver disease screen to include slit lamp eye examination for Kayser-Fleischer rings, serum ceruloplasmin and 24-hour urinary copper level, which led to the diagnosis. She improved clinically and biochemically with zinc acetate therapy. As screening for rare diseases is not always possible in low-income countries, this case demonstrates the usefulness of the basic LFT as a guide for suspecting Wilson’s disease in patients with liver disease. F1000 Research Limited 2022-03-03 /pmc/articles/PMC9010801/ /pubmed/35475033 http://dx.doi.org/10.12688/f1000research.54569.2 Text en Copyright: © 2022 Adhikari S et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Adhikari, Sudeep Shah, Prashant Kumar Sharma, Yuba Raj Case Report: Using basic liver function tests as a guide to suspected Wilson’s disease |
title | Case Report: Using basic liver function tests as a guide to suspected Wilson’s disease |
title_full | Case Report: Using basic liver function tests as a guide to suspected Wilson’s disease |
title_fullStr | Case Report: Using basic liver function tests as a guide to suspected Wilson’s disease |
title_full_unstemmed | Case Report: Using basic liver function tests as a guide to suspected Wilson’s disease |
title_short | Case Report: Using basic liver function tests as a guide to suspected Wilson’s disease |
title_sort | case report: using basic liver function tests as a guide to suspected wilson’s disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010801/ https://www.ncbi.nlm.nih.gov/pubmed/35475033 http://dx.doi.org/10.12688/f1000research.54569.2 |
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