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Time-keeping and decision-making in living cells: Part I
To survive and reproduce, a cell must process information from its environment and its own internal state and respond accordingly, in terms of metabolic activity, gene expression, movement, growth, division and differentiation. These signal–response decisions are made by complex networks of interact...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010849/ http://dx.doi.org/10.1098/rsfs.2022.0011 |
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author | Tyson, John J. Csikasz-Nagy, Attila Gonze, Didier Kim, Jae Kyoung Santos, Silvia Wolf, Jana |
author_facet | Tyson, John J. Csikasz-Nagy, Attila Gonze, Didier Kim, Jae Kyoung Santos, Silvia Wolf, Jana |
author_sort | Tyson, John J. |
collection | PubMed |
description | To survive and reproduce, a cell must process information from its environment and its own internal state and respond accordingly, in terms of metabolic activity, gene expression, movement, growth, division and differentiation. These signal–response decisions are made by complex networks of interacting genes and proteins, which function as biochemical switches and clocks, and other recognizable information-processing circuitry. This theme issue of Interface Focus (in two parts) brings together articles on time-keeping and decision-making in living cells—work that uses precise mathematical modelling of underlying molecular regulatory networks to understand important features of cell physiology. Part I focuses on time-keeping: mechanisms and dynamics of biological oscillators and modes of synchronization and entrainment of oscillators, with special attention to circadian clocks. |
format | Online Article Text |
id | pubmed-9010849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-90108492022-04-20 Time-keeping and decision-making in living cells: Part I Tyson, John J. Csikasz-Nagy, Attila Gonze, Didier Kim, Jae Kyoung Santos, Silvia Wolf, Jana Interface Focus Introduction To survive and reproduce, a cell must process information from its environment and its own internal state and respond accordingly, in terms of metabolic activity, gene expression, movement, growth, division and differentiation. These signal–response decisions are made by complex networks of interacting genes and proteins, which function as biochemical switches and clocks, and other recognizable information-processing circuitry. This theme issue of Interface Focus (in two parts) brings together articles on time-keeping and decision-making in living cells—work that uses precise mathematical modelling of underlying molecular regulatory networks to understand important features of cell physiology. Part I focuses on time-keeping: mechanisms and dynamics of biological oscillators and modes of synchronization and entrainment of oscillators, with special attention to circadian clocks. The Royal Society 2022-04-15 /pmc/articles/PMC9010849/ http://dx.doi.org/10.1098/rsfs.2022.0011 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Introduction Tyson, John J. Csikasz-Nagy, Attila Gonze, Didier Kim, Jae Kyoung Santos, Silvia Wolf, Jana Time-keeping and decision-making in living cells: Part I |
title | Time-keeping and decision-making in living cells: Part I |
title_full | Time-keeping and decision-making in living cells: Part I |
title_fullStr | Time-keeping and decision-making in living cells: Part I |
title_full_unstemmed | Time-keeping and decision-making in living cells: Part I |
title_short | Time-keeping and decision-making in living cells: Part I |
title_sort | time-keeping and decision-making in living cells: part i |
topic | Introduction |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010849/ http://dx.doi.org/10.1098/rsfs.2022.0011 |
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