Expression of Constitutive Fusion of Ubiquitin to PCNA Restores the Level of Immunoglobulin A/T Mutations During Somatic Hypermutation in the Ramos Cell Line

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a B cell specific process required for the generation of specific and high affinity antibodies during the maturation of the immune response against foreign antigens. This process depends on the activity of both activation-induced cytidine d...

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Detalles Bibliográficos
Autores principales: Lerner, Leticia K., Bonte, Dorine, Le Guillou, Morwenna, Mohammad, Mahwish Mian, Kasraian, Zeinab, Sarasin, Alain, Despras, Emmanuelle, Aoufouchi, Said
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010874/
https://www.ncbi.nlm.nih.gov/pubmed/35432321
http://dx.doi.org/10.3389/fimmu.2022.871766

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