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Geminivirus-Derived Vectors as Tools for Functional Genomics
A persistent issue in the agricultural sector worldwide is the intensive damage caused to crops by the geminivirus family of viruses. The diverse types of viruses, rapid virus evolution rate, and broad host range make this group of viruses one of the most devastating in nature, leading to millions o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010885/ https://www.ncbi.nlm.nih.gov/pubmed/35432267 http://dx.doi.org/10.3389/fmicb.2022.799345 |
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author | Bhattacharjee, Bipasha Hallan, Vipin |
author_facet | Bhattacharjee, Bipasha Hallan, Vipin |
author_sort | Bhattacharjee, Bipasha |
collection | PubMed |
description | A persistent issue in the agricultural sector worldwide is the intensive damage caused to crops by the geminivirus family of viruses. The diverse types of viruses, rapid virus evolution rate, and broad host range make this group of viruses one of the most devastating in nature, leading to millions of dollars’ worth of crop damage. Geminiviruses have a small genome and can be either monopartite or bipartite, with or without satellites. Their ability to independently replicate within the plant without integration into the host genome and the relatively easy handling make them excellent candidates for plant bioengineering. This aspect is of great importance as geminiviruses can act as natural nanoparticles in plants which can be utilized for a plethora of functions ranging from vaccine development systems to geminivirus-induced gene silencing (GIGS), through deconstructed viral vectors. Thus, the investigation of these plant viruses is pertinent to understanding their crucial roles in nature and subsequently utilizing them as beneficial tools in functional genomics. This review, therefore, highlights some of the characteristics of these viruses that can be deemed significant and the subsequent successful case studies for exploitation of these potentially significant pathogens for role mining in functional biology. |
format | Online Article Text |
id | pubmed-9010885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90108852022-04-16 Geminivirus-Derived Vectors as Tools for Functional Genomics Bhattacharjee, Bipasha Hallan, Vipin Front Microbiol Microbiology A persistent issue in the agricultural sector worldwide is the intensive damage caused to crops by the geminivirus family of viruses. The diverse types of viruses, rapid virus evolution rate, and broad host range make this group of viruses one of the most devastating in nature, leading to millions of dollars’ worth of crop damage. Geminiviruses have a small genome and can be either monopartite or bipartite, with or without satellites. Their ability to independently replicate within the plant without integration into the host genome and the relatively easy handling make them excellent candidates for plant bioengineering. This aspect is of great importance as geminiviruses can act as natural nanoparticles in plants which can be utilized for a plethora of functions ranging from vaccine development systems to geminivirus-induced gene silencing (GIGS), through deconstructed viral vectors. Thus, the investigation of these plant viruses is pertinent to understanding their crucial roles in nature and subsequently utilizing them as beneficial tools in functional genomics. This review, therefore, highlights some of the characteristics of these viruses that can be deemed significant and the subsequent successful case studies for exploitation of these potentially significant pathogens for role mining in functional biology. Frontiers Media S.A. 2022-04-01 /pmc/articles/PMC9010885/ /pubmed/35432267 http://dx.doi.org/10.3389/fmicb.2022.799345 Text en Copyright © 2022 Bhattacharjee and Hallan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Bhattacharjee, Bipasha Hallan, Vipin Geminivirus-Derived Vectors as Tools for Functional Genomics |
title | Geminivirus-Derived Vectors as Tools for Functional Genomics |
title_full | Geminivirus-Derived Vectors as Tools for Functional Genomics |
title_fullStr | Geminivirus-Derived Vectors as Tools for Functional Genomics |
title_full_unstemmed | Geminivirus-Derived Vectors as Tools for Functional Genomics |
title_short | Geminivirus-Derived Vectors as Tools for Functional Genomics |
title_sort | geminivirus-derived vectors as tools for functional genomics |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010885/ https://www.ncbi.nlm.nih.gov/pubmed/35432267 http://dx.doi.org/10.3389/fmicb.2022.799345 |
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