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Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis

PURPOSE: The aim of this study was to compare surgical outcomes after liver resection for hepatocellular carcinoma (HCC) according to tumor size using a large, nationwide cancer registry-based cohort and propensity score matching. METHODS: From 2008 to 2015, a total of 12,139 patients were diagnosed...

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Autores principales: Hong, Suk Kyun, Lee, Kwang-Woong, Lee, Sola, Hong, Su young, Suh, Sanggyun, Han, Eui Soo, Choi, YoungRok, Yi, Nam-Joon, Suh, Kyung-Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010965/
https://www.ncbi.nlm.nih.gov/pubmed/35475226
http://dx.doi.org/10.4174/astr.2022.102.4.193
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author Hong, Suk Kyun
Lee, Kwang-Woong
Lee, Sola
Hong, Su young
Suh, Sanggyun
Han, Eui Soo
Choi, YoungRok
Yi, Nam-Joon
Suh, Kyung-Suk
author_facet Hong, Suk Kyun
Lee, Kwang-Woong
Lee, Sola
Hong, Su young
Suh, Sanggyun
Han, Eui Soo
Choi, YoungRok
Yi, Nam-Joon
Suh, Kyung-Suk
author_sort Hong, Suk Kyun
collection PubMed
description PURPOSE: The aim of this study was to compare surgical outcomes after liver resection for hepatocellular carcinoma (HCC) according to tumor size using a large, nationwide cancer registry-based cohort and propensity score matching. METHODS: From 2008 to 2015, a total of 12,139 patients were diagnosed with liver cancer and registered in the Korean Primary Liver Cancer Registry. Patients without distant metastasis who underwent hepatectomy as a primary treatment were selected. We performed 1:1 propensity score matching between the small (<5 cm), large (≥5 cm and <10 cm), and huge (≥10 cm) groups. RESULTS: Overall, 265 patients in the small and large groups were compared, and 64 patients each in the large and huge groups were compared. The overall and progression-free survival rates were significantly lower in the large group than in the small group (P < 0.001 and P < 0.001, respectively). Overall survival tended to be poorer in the huge group than in the large group (P = 0.051). The progression-free survival rate was significantly lower in the huge group than in the large group (P = 0.002). CONCLUSION: Although primary liver resection can be considered even in patients with huge HCC, greater caution with careful screening for recurrence is needed.
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spelling pubmed-90109652022-04-25 Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis Hong, Suk Kyun Lee, Kwang-Woong Lee, Sola Hong, Su young Suh, Sanggyun Han, Eui Soo Choi, YoungRok Yi, Nam-Joon Suh, Kyung-Suk Ann Surg Treat Res Original Article PURPOSE: The aim of this study was to compare surgical outcomes after liver resection for hepatocellular carcinoma (HCC) according to tumor size using a large, nationwide cancer registry-based cohort and propensity score matching. METHODS: From 2008 to 2015, a total of 12,139 patients were diagnosed with liver cancer and registered in the Korean Primary Liver Cancer Registry. Patients without distant metastasis who underwent hepatectomy as a primary treatment were selected. We performed 1:1 propensity score matching between the small (<5 cm), large (≥5 cm and <10 cm), and huge (≥10 cm) groups. RESULTS: Overall, 265 patients in the small and large groups were compared, and 64 patients each in the large and huge groups were compared. The overall and progression-free survival rates were significantly lower in the large group than in the small group (P < 0.001 and P < 0.001, respectively). Overall survival tended to be poorer in the huge group than in the large group (P = 0.051). The progression-free survival rate was significantly lower in the huge group than in the large group (P = 0.002). CONCLUSION: Although primary liver resection can be considered even in patients with huge HCC, greater caution with careful screening for recurrence is needed. The Korean Surgical Society 2022-04 2022-04-05 /pmc/articles/PMC9010965/ /pubmed/35475226 http://dx.doi.org/10.4174/astr.2022.102.4.193 Text en Copyright © 2022, the Korean Surgical Society https://creativecommons.org/licenses/by-nc/4.0/Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hong, Suk Kyun
Lee, Kwang-Woong
Lee, Sola
Hong, Su young
Suh, Sanggyun
Han, Eui Soo
Choi, YoungRok
Yi, Nam-Joon
Suh, Kyung-Suk
Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis
title Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis
title_full Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis
title_fullStr Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis
title_full_unstemmed Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis
title_short Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis
title_sort impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010965/
https://www.ncbi.nlm.nih.gov/pubmed/35475226
http://dx.doi.org/10.4174/astr.2022.102.4.193
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