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Clinical Epidemiology of Pediatric COVID-19 Delta Variant Cases From North Sumatra, Indonesia

The Delta variant of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) dominated the coronavirus disease 2019 (COVID-19) pandemic in 2021. Here we report the Delta variant among pediatric cases in North Sumatra, Indonesia, from June to July 2021. Whole-genome sequencing (WGS) from 18 new...

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Autores principales: Kusumawati, R. Lia, Lubis, Inke Nadia Diniyanti, Kumaheri, Meutia Ayuputeri, Pradipta, Ariel, Faksri, Kiatichai, Mutiara, Mutiara, Shankar, Anuraj H., Tania, Tryna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010973/
https://www.ncbi.nlm.nih.gov/pubmed/35433558
http://dx.doi.org/10.3389/fped.2022.810404
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author Kusumawati, R. Lia
Lubis, Inke Nadia Diniyanti
Kumaheri, Meutia Ayuputeri
Pradipta, Ariel
Faksri, Kiatichai
Mutiara, Mutiara
Shankar, Anuraj H.
Tania, Tryna
author_facet Kusumawati, R. Lia
Lubis, Inke Nadia Diniyanti
Kumaheri, Meutia Ayuputeri
Pradipta, Ariel
Faksri, Kiatichai
Mutiara, Mutiara
Shankar, Anuraj H.
Tania, Tryna
author_sort Kusumawati, R. Lia
collection PubMed
description The Delta variant of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) dominated the coronavirus disease 2019 (COVID-19) pandemic in 2021. Here we report the Delta variant among pediatric cases in North Sumatra, Indonesia, from June to July 2021. Whole-genome sequencing (WGS) from 18 new COVID-19 pediatric patients showed that six were B.1.459 and six were B.1.466.2, known variants in Indonesia in clade 20A. Six were the Delta variant B.1.617.2 of clade 21A, with five on one branch and one on a distant branch consistent with that patient's geographic separation, suggesting at least two introductions to the region. Variants tended to be spatially clustered, and four children with Delta variant had an adult infected household member, all of whom had lower real-time polymerase chain reaction cycle threshold (Ct) values compared with the child. No temporal trends were observed for Ct. These data support a paradigm shift with children being highly susceptible to the Delta variant and a priority for vaccination.
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spelling pubmed-90109732022-04-16 Clinical Epidemiology of Pediatric COVID-19 Delta Variant Cases From North Sumatra, Indonesia Kusumawati, R. Lia Lubis, Inke Nadia Diniyanti Kumaheri, Meutia Ayuputeri Pradipta, Ariel Faksri, Kiatichai Mutiara, Mutiara Shankar, Anuraj H. Tania, Tryna Front Pediatr Pediatrics The Delta variant of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) dominated the coronavirus disease 2019 (COVID-19) pandemic in 2021. Here we report the Delta variant among pediatric cases in North Sumatra, Indonesia, from June to July 2021. Whole-genome sequencing (WGS) from 18 new COVID-19 pediatric patients showed that six were B.1.459 and six were B.1.466.2, known variants in Indonesia in clade 20A. Six were the Delta variant B.1.617.2 of clade 21A, with five on one branch and one on a distant branch consistent with that patient's geographic separation, suggesting at least two introductions to the region. Variants tended to be spatially clustered, and four children with Delta variant had an adult infected household member, all of whom had lower real-time polymerase chain reaction cycle threshold (Ct) values compared with the child. No temporal trends were observed for Ct. These data support a paradigm shift with children being highly susceptible to the Delta variant and a priority for vaccination. Frontiers Media S.A. 2022-04-01 /pmc/articles/PMC9010973/ /pubmed/35433558 http://dx.doi.org/10.3389/fped.2022.810404 Text en Copyright © 2022 Kusumawati, Lubis, Kumaheri, Pradipta, Faksri, Mutiara, Shankar and Tania. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Kusumawati, R. Lia
Lubis, Inke Nadia Diniyanti
Kumaheri, Meutia Ayuputeri
Pradipta, Ariel
Faksri, Kiatichai
Mutiara, Mutiara
Shankar, Anuraj H.
Tania, Tryna
Clinical Epidemiology of Pediatric COVID-19 Delta Variant Cases From North Sumatra, Indonesia
title Clinical Epidemiology of Pediatric COVID-19 Delta Variant Cases From North Sumatra, Indonesia
title_full Clinical Epidemiology of Pediatric COVID-19 Delta Variant Cases From North Sumatra, Indonesia
title_fullStr Clinical Epidemiology of Pediatric COVID-19 Delta Variant Cases From North Sumatra, Indonesia
title_full_unstemmed Clinical Epidemiology of Pediatric COVID-19 Delta Variant Cases From North Sumatra, Indonesia
title_short Clinical Epidemiology of Pediatric COVID-19 Delta Variant Cases From North Sumatra, Indonesia
title_sort clinical epidemiology of pediatric covid-19 delta variant cases from north sumatra, indonesia
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010973/
https://www.ncbi.nlm.nih.gov/pubmed/35433558
http://dx.doi.org/10.3389/fped.2022.810404
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