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Aberrant Neural Response to Social Exclusion Without Significantly Greater Distress in Youth With Bipolar Disorder: Preliminary Findings

BACKGROUND: Little is known about the effects of social exclusion on youth with bipolar disorder (BD). Understanding these effects and the functional neural correlates of social exclusion in youth with BD may establish differences from healthy youth and help identify areas of intervention. METHODS:...

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Autores principales: Roybal, Donna J., Cosgrove, Victoria E., Kelley, Ryan, Smallwood Shoukry, Rachel, Larios, Rose Marie, Novy, Blake, Chang, Kiki D., Garrett, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011186/
https://www.ncbi.nlm.nih.gov/pubmed/35432046
http://dx.doi.org/10.3389/fpsyt.2022.687052
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author Roybal, Donna J.
Cosgrove, Victoria E.
Kelley, Ryan
Smallwood Shoukry, Rachel
Larios, Rose Marie
Novy, Blake
Chang, Kiki D.
Garrett, Amy S.
author_facet Roybal, Donna J.
Cosgrove, Victoria E.
Kelley, Ryan
Smallwood Shoukry, Rachel
Larios, Rose Marie
Novy, Blake
Chang, Kiki D.
Garrett, Amy S.
author_sort Roybal, Donna J.
collection PubMed
description BACKGROUND: Little is known about the effects of social exclusion on youth with bipolar disorder (BD). Understanding these effects and the functional neural correlates of social exclusion in youth with BD may establish differences from healthy youth and help identify areas of intervention. METHODS: We investigated brain function in 19 youth with BD and 14 age and gender matched healthy control (HC) participants while performing Cyberball, an fMRI social exclusion task. Whole brain activation, region-of-interest, and functional connectivity were compared between groups and examined with behavioral measures. RESULTS: Compared with the HC group, youth with BD exhibited greater activation in the left fusiform gyrus (FFG) during social exclusion. Functional connectivity between the left FFG and the posterior cingulate/precuneus was significantly greater in the HC compared with the BD group. For the HC group only, age and subjective distress during Cyberball significantly predicted mean FFG activation. No significant differences in distress during social exclusion were found between groups. CONCLUSION: Although preliminary due to small sample size, these data suggest that youth with BD process social exclusion in a manner that focuses on basic visual information while healthy youth make use of past experiences to interpret current social encounters. This difference may account for the social cognitive issues experienced by youth with BD, which can lead to more severe anxiety and mood symptoms.
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spelling pubmed-90111862022-04-16 Aberrant Neural Response to Social Exclusion Without Significantly Greater Distress in Youth With Bipolar Disorder: Preliminary Findings Roybal, Donna J. Cosgrove, Victoria E. Kelley, Ryan Smallwood Shoukry, Rachel Larios, Rose Marie Novy, Blake Chang, Kiki D. Garrett, Amy S. Front Psychiatry Psychiatry BACKGROUND: Little is known about the effects of social exclusion on youth with bipolar disorder (BD). Understanding these effects and the functional neural correlates of social exclusion in youth with BD may establish differences from healthy youth and help identify areas of intervention. METHODS: We investigated brain function in 19 youth with BD and 14 age and gender matched healthy control (HC) participants while performing Cyberball, an fMRI social exclusion task. Whole brain activation, region-of-interest, and functional connectivity were compared between groups and examined with behavioral measures. RESULTS: Compared with the HC group, youth with BD exhibited greater activation in the left fusiform gyrus (FFG) during social exclusion. Functional connectivity between the left FFG and the posterior cingulate/precuneus was significantly greater in the HC compared with the BD group. For the HC group only, age and subjective distress during Cyberball significantly predicted mean FFG activation. No significant differences in distress during social exclusion were found between groups. CONCLUSION: Although preliminary due to small sample size, these data suggest that youth with BD process social exclusion in a manner that focuses on basic visual information while healthy youth make use of past experiences to interpret current social encounters. This difference may account for the social cognitive issues experienced by youth with BD, which can lead to more severe anxiety and mood symptoms. Frontiers Media S.A. 2022-04-01 /pmc/articles/PMC9011186/ /pubmed/35432046 http://dx.doi.org/10.3389/fpsyt.2022.687052 Text en Copyright © 2022 Roybal, Cosgrove, Kelley, Smallwood Shoukry, Larios, Novy, Chang and Garrett. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Roybal, Donna J.
Cosgrove, Victoria E.
Kelley, Ryan
Smallwood Shoukry, Rachel
Larios, Rose Marie
Novy, Blake
Chang, Kiki D.
Garrett, Amy S.
Aberrant Neural Response to Social Exclusion Without Significantly Greater Distress in Youth With Bipolar Disorder: Preliminary Findings
title Aberrant Neural Response to Social Exclusion Without Significantly Greater Distress in Youth With Bipolar Disorder: Preliminary Findings
title_full Aberrant Neural Response to Social Exclusion Without Significantly Greater Distress in Youth With Bipolar Disorder: Preliminary Findings
title_fullStr Aberrant Neural Response to Social Exclusion Without Significantly Greater Distress in Youth With Bipolar Disorder: Preliminary Findings
title_full_unstemmed Aberrant Neural Response to Social Exclusion Without Significantly Greater Distress in Youth With Bipolar Disorder: Preliminary Findings
title_short Aberrant Neural Response to Social Exclusion Without Significantly Greater Distress in Youth With Bipolar Disorder: Preliminary Findings
title_sort aberrant neural response to social exclusion without significantly greater distress in youth with bipolar disorder: preliminary findings
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011186/
https://www.ncbi.nlm.nih.gov/pubmed/35432046
http://dx.doi.org/10.3389/fpsyt.2022.687052
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