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Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study

Sarcoptic mange is considered the main driver of demographic declines occurred in the last decades in Iberian ibex (Capra pyrenaica) populations. Mass treatment campaigns by administration of in-feed acaricides are used as a measure to mitigate the impact of mange in the affected populations. Howeve...

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Autores principales: Moroni, Barbara, Granados Torres, José Enrique, López-Olvera, Jorge Ramón, Espinosa Cerrato, José, Ráez Bravo, Arián, Mentaberre, Gregorio, Fandos, Paulino, Pazzi, Marco, Romagnoli, Monica, Gardini, Giulia, Rossi, Luca, Valldeperes, Marta, Serrano, Emmanuel, Ramos, Blanca, Odore, Rosangela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011188/
https://www.ncbi.nlm.nih.gov/pubmed/35433921
http://dx.doi.org/10.3389/fvets.2022.830157
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author Moroni, Barbara
Granados Torres, José Enrique
López-Olvera, Jorge Ramón
Espinosa Cerrato, José
Ráez Bravo, Arián
Mentaberre, Gregorio
Fandos, Paulino
Pazzi, Marco
Romagnoli, Monica
Gardini, Giulia
Rossi, Luca
Valldeperes, Marta
Serrano, Emmanuel
Ramos, Blanca
Odore, Rosangela
author_facet Moroni, Barbara
Granados Torres, José Enrique
López-Olvera, Jorge Ramón
Espinosa Cerrato, José
Ráez Bravo, Arián
Mentaberre, Gregorio
Fandos, Paulino
Pazzi, Marco
Romagnoli, Monica
Gardini, Giulia
Rossi, Luca
Valldeperes, Marta
Serrano, Emmanuel
Ramos, Blanca
Odore, Rosangela
author_sort Moroni, Barbara
collection PubMed
description Sarcoptic mange is considered the main driver of demographic declines occurred in the last decades in Iberian ibex (Capra pyrenaica) populations. Mass treatment campaigns by administration of in-feed acaricides are used as a measure to mitigate the impact of mange in the affected populations. However, there are no data on ivermectin (IVM) pharmacokinetics in this wild caprine, and the treatment through medicated feed is not endorsed by evidence on its effectiveness. The aim of this study is to determine the pharmacokinetic profile of IVM in plasma samples of ibexes after the experimental oral administration of IVM, using high performance liquid chromatography (HPLC) with automated solid phase extraction and fluorescence detection. A dose of 500 μg of IVM per body weight was orally administered in a feed bolus to nine healthy adult ibexes (seven males and two females). Blood samples were collected by jugular venipuncture into heparin-coated tubes at day 1, 2, 3, 4, 7, 10, 15, and 45 post-administration (dpa). The highest plasma concentration of IVM (Cmax = 3.4 ng/ml) was detected 24 h after the oral administration (T1), followed by a rapid decrease during the first week post-administration. Our results reveal that plasma IVM concentration drops drastically within 5 days of ingestion, questioning the effectiveness of a single in-feed dose of this drug to control sarcoptic mange. To the best of our knowledge, this is the first study on plasma availability of oral IVM in ibexes and in any wild ungulate species.
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spelling pubmed-90111882022-04-16 Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study Moroni, Barbara Granados Torres, José Enrique López-Olvera, Jorge Ramón Espinosa Cerrato, José Ráez Bravo, Arián Mentaberre, Gregorio Fandos, Paulino Pazzi, Marco Romagnoli, Monica Gardini, Giulia Rossi, Luca Valldeperes, Marta Serrano, Emmanuel Ramos, Blanca Odore, Rosangela Front Vet Sci Veterinary Science Sarcoptic mange is considered the main driver of demographic declines occurred in the last decades in Iberian ibex (Capra pyrenaica) populations. Mass treatment campaigns by administration of in-feed acaricides are used as a measure to mitigate the impact of mange in the affected populations. However, there are no data on ivermectin (IVM) pharmacokinetics in this wild caprine, and the treatment through medicated feed is not endorsed by evidence on its effectiveness. The aim of this study is to determine the pharmacokinetic profile of IVM in plasma samples of ibexes after the experimental oral administration of IVM, using high performance liquid chromatography (HPLC) with automated solid phase extraction and fluorescence detection. A dose of 500 μg of IVM per body weight was orally administered in a feed bolus to nine healthy adult ibexes (seven males and two females). Blood samples were collected by jugular venipuncture into heparin-coated tubes at day 1, 2, 3, 4, 7, 10, 15, and 45 post-administration (dpa). The highest plasma concentration of IVM (Cmax = 3.4 ng/ml) was detected 24 h after the oral administration (T1), followed by a rapid decrease during the first week post-administration. Our results reveal that plasma IVM concentration drops drastically within 5 days of ingestion, questioning the effectiveness of a single in-feed dose of this drug to control sarcoptic mange. To the best of our knowledge, this is the first study on plasma availability of oral IVM in ibexes and in any wild ungulate species. Frontiers Media S.A. 2022-04-01 /pmc/articles/PMC9011188/ /pubmed/35433921 http://dx.doi.org/10.3389/fvets.2022.830157 Text en Copyright © 2022 Moroni, Granados Torres, López-Olvera, Espinosa Cerrato, Ráez Bravo, Mentaberre, Fandos, Pazzi, Romagnoli, Gardini, Rossi, Valldeperes, Serrano, Ramos and Odore. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Moroni, Barbara
Granados Torres, José Enrique
López-Olvera, Jorge Ramón
Espinosa Cerrato, José
Ráez Bravo, Arián
Mentaberre, Gregorio
Fandos, Paulino
Pazzi, Marco
Romagnoli, Monica
Gardini, Giulia
Rossi, Luca
Valldeperes, Marta
Serrano, Emmanuel
Ramos, Blanca
Odore, Rosangela
Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study
title Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study
title_full Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study
title_fullStr Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study
title_full_unstemmed Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study
title_short Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study
title_sort ivermectin plasma concentration in iberian ibex (capra pyrenaica) following oral administration: a pilot study
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011188/
https://www.ncbi.nlm.nih.gov/pubmed/35433921
http://dx.doi.org/10.3389/fvets.2022.830157
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