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Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey

BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers in China, and most CRC patients have already reached an advanced stage by the time of initial diagnosis. Due to the loss of health as a result of cancer, it has consequence on the treatment which may affect the psychophysical and...

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Autores principales: Yu, Yan-Qin, Ma, Li, Wang, Wen-Jun, Zhao, Yu-Qian, Xu, Hui-Fang, Cao, Ji, Li, Li, Hao, Jin-Qi, Gao, Jing-Ru, Gu, Xiao-Fen, Liu, Yun-Yong, Huang, Juan-Xiu, Fan, Yan-Ping, Du, Ling-Bin, Cao, He-Lu, Feng, Chang-Yan, Zhu, Qian, Wang, Xiao-Hui, Du, Jing-Chang, Bangura, Mohamed S., Zhang, Xi, Zhang, Shao-Kai, Qiao, You-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011208/
https://www.ncbi.nlm.nih.gov/pubmed/35433947
http://dx.doi.org/10.21037/atm-22-991
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author Yu, Yan-Qin
Ma, Li
Wang, Wen-Jun
Zhao, Yu-Qian
Xu, Hui-Fang
Cao, Ji
Li, Li
Hao, Jin-Qi
Gao, Jing-Ru
Gu, Xiao-Fen
Liu, Yun-Yong
Huang, Juan-Xiu
Fan, Yan-Ping
Du, Ling-Bin
Cao, He-Lu
Feng, Chang-Yan
Zhu, Qian
Wang, Xiao-Hui
Du, Jing-Chang
Bangura, Mohamed S.
Zhang, Xi
Zhang, Shao-Kai
Qiao, You-Lin
author_facet Yu, Yan-Qin
Ma, Li
Wang, Wen-Jun
Zhao, Yu-Qian
Xu, Hui-Fang
Cao, Ji
Li, Li
Hao, Jin-Qi
Gao, Jing-Ru
Gu, Xiao-Fen
Liu, Yun-Yong
Huang, Juan-Xiu
Fan, Yan-Ping
Du, Ling-Bin
Cao, He-Lu
Feng, Chang-Yan
Zhu, Qian
Wang, Xiao-Hui
Du, Jing-Chang
Bangura, Mohamed S.
Zhang, Xi
Zhang, Shao-Kai
Qiao, You-Lin
author_sort Yu, Yan-Qin
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers in China, and most CRC patients have already reached an advanced stage by the time of initial diagnosis. Due to the loss of health as a result of cancer, it has consequence on the treatment which may affect the psychophysical and social impairment of CRC patients. These indicators (psychophysical, function and social impairment) affect the health-related quality of life (HRQOL). There are limited studies that focus on advanced CRC patients in China. This study aimed to assess the HRQOL and its associated factors of advanced CRC patients in China. METHODS: This was a cross-sectional, nationwide, hospital-based, and multi-center survey. According to the traditional administrative district definition, we selected 19 hospitals in 7 regions by multi-stage stratified sampling in China. For each eligible CRC patient with stage III or IV in the selected hospitals, socio-demographics, clinical information, and HRQOL were collected based on patients’ self-reporting and/or medical records between March 2020 and March 2021. Patients completed the Functional Assessment of Cancer Therapy Colorectal (FACT-C) plus-traditional Chinese version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-9. RESULTS: A total of 4,589 CRC patients (mean age 60.1 years, including 2,730 males and 1,859 females) were included. The total score of HRQOL in population was 128.2±24.70. There were significant differences in the overall score of HRQOL in gender, education level, occupation, region, disease type, and disease stage (P<0.05). The score of HRQOL was better in males, undergraduates and above, unemployed/laid-off, and southwestern and central China. Multivariate analysis showed that education level, occupation, location, number of hospitals visited and treatment methods, and gender were associated with utilities of CRC patients. CONCLUSIONS: The HRQOL is an important outcome measure for CRC patients. The HRQOL scores differed according to socio-demographic and clinical characteristics, and findings of these factors were associated with education level, occupation, region, number of visited and treatment methods, and gender.
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spelling pubmed-90112082022-04-16 Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey Yu, Yan-Qin Ma, Li Wang, Wen-Jun Zhao, Yu-Qian Xu, Hui-Fang Cao, Ji Li, Li Hao, Jin-Qi Gao, Jing-Ru Gu, Xiao-Fen Liu, Yun-Yong Huang, Juan-Xiu Fan, Yan-Ping Du, Ling-Bin Cao, He-Lu Feng, Chang-Yan Zhu, Qian Wang, Xiao-Hui Du, Jing-Chang Bangura, Mohamed S. Zhang, Xi Zhang, Shao-Kai Qiao, You-Lin Ann Transl Med Original Article BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers in China, and most CRC patients have already reached an advanced stage by the time of initial diagnosis. Due to the loss of health as a result of cancer, it has consequence on the treatment which may affect the psychophysical and social impairment of CRC patients. These indicators (psychophysical, function and social impairment) affect the health-related quality of life (HRQOL). There are limited studies that focus on advanced CRC patients in China. This study aimed to assess the HRQOL and its associated factors of advanced CRC patients in China. METHODS: This was a cross-sectional, nationwide, hospital-based, and multi-center survey. According to the traditional administrative district definition, we selected 19 hospitals in 7 regions by multi-stage stratified sampling in China. For each eligible CRC patient with stage III or IV in the selected hospitals, socio-demographics, clinical information, and HRQOL were collected based on patients’ self-reporting and/or medical records between March 2020 and March 2021. Patients completed the Functional Assessment of Cancer Therapy Colorectal (FACT-C) plus-traditional Chinese version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-9. RESULTS: A total of 4,589 CRC patients (mean age 60.1 years, including 2,730 males and 1,859 females) were included. The total score of HRQOL in population was 128.2±24.70. There were significant differences in the overall score of HRQOL in gender, education level, occupation, region, disease type, and disease stage (P<0.05). The score of HRQOL was better in males, undergraduates and above, unemployed/laid-off, and southwestern and central China. Multivariate analysis showed that education level, occupation, location, number of hospitals visited and treatment methods, and gender were associated with utilities of CRC patients. CONCLUSIONS: The HRQOL is an important outcome measure for CRC patients. The HRQOL scores differed according to socio-demographic and clinical characteristics, and findings of these factors were associated with education level, occupation, region, number of visited and treatment methods, and gender. AME Publishing Company 2022-03 /pmc/articles/PMC9011208/ /pubmed/35433947 http://dx.doi.org/10.21037/atm-22-991 Text en 2022 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Yu, Yan-Qin
Ma, Li
Wang, Wen-Jun
Zhao, Yu-Qian
Xu, Hui-Fang
Cao, Ji
Li, Li
Hao, Jin-Qi
Gao, Jing-Ru
Gu, Xiao-Fen
Liu, Yun-Yong
Huang, Juan-Xiu
Fan, Yan-Ping
Du, Ling-Bin
Cao, He-Lu
Feng, Chang-Yan
Zhu, Qian
Wang, Xiao-Hui
Du, Jing-Chang
Bangura, Mohamed S.
Zhang, Xi
Zhang, Shao-Kai
Qiao, You-Lin
Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey
title Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey
title_full Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey
title_fullStr Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey
title_full_unstemmed Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey
title_short Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey
title_sort health-related quality of life in advanced colorectal cancer patients in china: a nationwide hospital-based survey
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011208/
https://www.ncbi.nlm.nih.gov/pubmed/35433947
http://dx.doi.org/10.21037/atm-22-991
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