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Impact of anemia on prognosis in tuberculosis patients
BACKGROUND: Anemia is one of the risk factors for tuberculosis (TB), and more than 90% of TB patients suffer from anemia. The majority tuberculosis patients who had poor prognosis experienced anemia during the course of treatment. The objective of our study is to analyse the influences of anemia on...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011296/ https://www.ncbi.nlm.nih.gov/pubmed/35433932 http://dx.doi.org/10.21037/atm-22-679 |
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author | Luo, Mengxing Liu, Ming Wu, Xiaocui Wu, Yaxing Yang, Hua Qin, Lianhua Yu, Fangyong Hu, Yang Liu, Zhonghua |
author_facet | Luo, Mengxing Liu, Ming Wu, Xiaocui Wu, Yaxing Yang, Hua Qin, Lianhua Yu, Fangyong Hu, Yang Liu, Zhonghua |
author_sort | Luo, Mengxing |
collection | PubMed |
description | BACKGROUND: Anemia is one of the risk factors for tuberculosis (TB), and more than 90% of TB patients suffer from anemia. The majority tuberculosis patients who had poor prognosis experienced anemia during the course of treatment. The objective of our study is to analyse the influences of anemia on the prognosis of tuberculosis patients in terms of pulmonary M. tuberculosis loads, lung pathology, and clinical factors. METHODS: In this retrospective cohort study, 155 TB patients in Shanghai were divided into the anemia-tuberculosis (A-TB) group and non-anemia-tuberculosis (NA-TB) group. We analysed bacteria counts in sputum smear and sputum smear conversion time between two groups. We evaluated the pulmonary pathology of cavity and effusion in A-TB patients. Logistic regression analysis was performed to explore the potential correlations of anemia with sputum bacterial load and pulmonary pathology. We compared clinical factors including the immune factors and inflammatory cells. RESULTS: Compared with the NA-TB (n=89) group, the A-TB group (n=66) had poorer improvement of lung injury in terms of cavity closure (4.7±3.59 vs. 10.56±7.42; P=0.036) and fluid improvement [4 (30.77%) vs. 12 (92.31%); P=0.001] during conventional treatment. At the start of treatment, the immune factors complement 4 (C4) [0.25 (0.19, 0.295) vs. 0.3086±0.076; P=0.006] and C-reactive protein (CRP) [3.2 (3.2, 21.5) vs. 19.5 (6.25, 78.35); P=0.016] were significantly higher in A-TB with NA-TB. During the course of treatment, the gradual decrease in the absolute number of lymphocytes (LYM#) (P=0.0012, r=−0.3400) and the gradual increase in the absolute number of monocytes (MONO#) (P=0.0050, r=0.2968), the absolute number of basophils (BASO#) (P=0.0213, r=0.2451), the red blood cell distribution width-coefficient (RDW-CV) (P=0.0136, r=0.2651), suggesting poor prognosis in anemic TB patients. CONCLUSIONS: Anemia is a risk factor for lung injury in TB patients. Inflammatory factors and inflammatory cells are increased during treatment in A-TB patients. |
format | Online Article Text |
id | pubmed-9011296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-90112962022-04-16 Impact of anemia on prognosis in tuberculosis patients Luo, Mengxing Liu, Ming Wu, Xiaocui Wu, Yaxing Yang, Hua Qin, Lianhua Yu, Fangyong Hu, Yang Liu, Zhonghua Ann Transl Med Original Article BACKGROUND: Anemia is one of the risk factors for tuberculosis (TB), and more than 90% of TB patients suffer from anemia. The majority tuberculosis patients who had poor prognosis experienced anemia during the course of treatment. The objective of our study is to analyse the influences of anemia on the prognosis of tuberculosis patients in terms of pulmonary M. tuberculosis loads, lung pathology, and clinical factors. METHODS: In this retrospective cohort study, 155 TB patients in Shanghai were divided into the anemia-tuberculosis (A-TB) group and non-anemia-tuberculosis (NA-TB) group. We analysed bacteria counts in sputum smear and sputum smear conversion time between two groups. We evaluated the pulmonary pathology of cavity and effusion in A-TB patients. Logistic regression analysis was performed to explore the potential correlations of anemia with sputum bacterial load and pulmonary pathology. We compared clinical factors including the immune factors and inflammatory cells. RESULTS: Compared with the NA-TB (n=89) group, the A-TB group (n=66) had poorer improvement of lung injury in terms of cavity closure (4.7±3.59 vs. 10.56±7.42; P=0.036) and fluid improvement [4 (30.77%) vs. 12 (92.31%); P=0.001] during conventional treatment. At the start of treatment, the immune factors complement 4 (C4) [0.25 (0.19, 0.295) vs. 0.3086±0.076; P=0.006] and C-reactive protein (CRP) [3.2 (3.2, 21.5) vs. 19.5 (6.25, 78.35); P=0.016] were significantly higher in A-TB with NA-TB. During the course of treatment, the gradual decrease in the absolute number of lymphocytes (LYM#) (P=0.0012, r=−0.3400) and the gradual increase in the absolute number of monocytes (MONO#) (P=0.0050, r=0.2968), the absolute number of basophils (BASO#) (P=0.0213, r=0.2451), the red blood cell distribution width-coefficient (RDW-CV) (P=0.0136, r=0.2651), suggesting poor prognosis in anemic TB patients. CONCLUSIONS: Anemia is a risk factor for lung injury in TB patients. Inflammatory factors and inflammatory cells are increased during treatment in A-TB patients. AME Publishing Company 2022-03 /pmc/articles/PMC9011296/ /pubmed/35433932 http://dx.doi.org/10.21037/atm-22-679 Text en 2022 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Luo, Mengxing Liu, Ming Wu, Xiaocui Wu, Yaxing Yang, Hua Qin, Lianhua Yu, Fangyong Hu, Yang Liu, Zhonghua Impact of anemia on prognosis in tuberculosis patients |
title | Impact of anemia on prognosis in tuberculosis patients |
title_full | Impact of anemia on prognosis in tuberculosis patients |
title_fullStr | Impact of anemia on prognosis in tuberculosis patients |
title_full_unstemmed | Impact of anemia on prognosis in tuberculosis patients |
title_short | Impact of anemia on prognosis in tuberculosis patients |
title_sort | impact of anemia on prognosis in tuberculosis patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011296/ https://www.ncbi.nlm.nih.gov/pubmed/35433932 http://dx.doi.org/10.21037/atm-22-679 |
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