Cargando…

Acteoside protects retinal ganglion cells from experimental glaucoma by activating the PI3K/AKT signaling pathway via caveolin 1 upregulation

BACKGROUND: Glaucoma is the second leading cause of blindness in the world and is characterized by optic neuropathy and degeneration of retinal ganglion cells (RGCs). Our preliminary research found that acteoside can inhibit autophagy-induced apoptosis of RGCs via the phosphatidylinositol 3-kinase (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xi, Xiaoting, Chen, Qianbo, Ma, Jia, Wang, Xuewei, Xia, Yuan, Wen, Xuewei, Cai, Bin, Li, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011318/ https://www.ncbi.nlm.nih.gov/pubmed/35433984 http://dx.doi.org/10.21037/atm-22-136

Ejemplares similares

Acteoside inhibits autophagic apoptosis of retinal ganglion cells to rescue glaucoma‐induced optic atrophy
por: Chen, Qianbo, et al.
Publicado: (2019)

Acteoside attenuates hydrogen peroxide-induced injury of retinal ganglion cells via the CASC2/miR-155/mTOR axis
por: Xi, Xiaoting, et al.
Publicado: (2022)

Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway
por: Wen, Xuewei, et al.
Publicado: (2022)

Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental Glaucoma
por: Hu, Xinxin, et al.
Publicado: (2018)

Overexpression of parkin protects retinal ganglion cells in experimental glaucoma
por: Dai, Yi, et al.
Publicado: (2018)

Retinal ganglion cells adapt to ionic stress in experimental glaucoma
por: Boal, Andrew M., et al.
Publicado: (2023)

Intrinsically photosensitive retinal ganglion cells in glaucoma
por: Gao, Jingyi, et al.
Publicado: (2022)

Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma
por: Quigley, Harry A., et al.
Publicado: (2015)

Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma
por: Yang, Xiangjun, et al.
Publicado: (2021)

Insulin upregulates betatrophin expression via PI3K/Akt pathway
por: Lu, Puhan, et al.
Publicado: (2017)

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity
por: Conde-Perez, Alejandro, et al.
Publicado: (2015)

Antioxidant Activity and Acteoside Analysis of Abeliophyllum distichum
por: Lee, Hak-Dong, et al.
Publicado: (2020)

Imaging of retinal ganglion cells in glaucoma: pitfalls and challenges
por: Werkmeister, R. M., et al.
Publicado: (2013)

Caveolin-1 Protects Retinal Ganglion Cells against Acute Ocular Hypertension Injury via Modulating Microglial Phenotypes and Distribution and Activating AKT pathway
por: Zhang, Liwei, et al.
Publicado: (2017)

Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma
por: Geva, Michal, et al.
Publicado: (2021)

7,8-Dihydroxiflavone Protects Adult Rat Axotomized Retinal Ganglion Cells through MAPK/ERK and PI3K/AKT Activation
por: Galindo-Romero, Caridad, et al.
Publicado: (2021)

Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner
por: Abbasi, Mojdeh, et al.
Publicado: (2021)

Fenofibrate Ameliorates Retinal Pigment Epithelium Injury Induced by Excessive Fat Through Upregulation of PI3K/AKT Signaling
por: Wang, Xue, et al.
Publicado: (2023)

Herbal Substance, Acteoside, Alleviates Intestinal Mucositis in Mice
por: Reinke, Daniel, et al.
Publicado: (2015)

The pharmacokinetic property and pharmacological activity of acteoside: A review
por: Xiao, Yaosheng, et al.
Publicado: (2022)

Ligustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway
por: Du, Hong-yan, et al.
Publicado: (2021)

Neuroprotective and neuroregenerative effects of CRMP-5 on retinal ganglion cells in an experimental in vivo and in vitro model of glaucoma
por: Lauzi, Jasmin, et al.
Publicado: (2019)

The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models
por: Rosignol, Ines, et al.
Publicado: (2020)

T and B Lymphocyte Deficiency in Rag1−/− Mice Reduces Retinal Ganglion Cell Loss in Experimental Glaucoma
por: Gramlich, Oliver W., et al.
Publicado: (2020)

L- and T-type Ca(2+) channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma
por: Wang, Hong-Ning, et al.
Publicado: (2022)

Upregulation of the PI3K/Akt Pathway in the Tumorigenesis of Canine Thyroid Carcinoma
por: Campos, M., et al.
Publicado: (2014)

Pulsatilla decoction alleviates colitis by enhancing autophagy and regulating PI3K-Akt-mTORC1 signaling pathway
por: Wang, Xuewei, et al.
Publicado: (2022)

Lidocaine liposome modified with folic acid suppresses the proliferation and motility of glioma cells via targeting the PI3K/AKT pathway
por: Li, Dedong, et al.
Publicado: (2021)

Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma
por: Williams, Pete A., et al.
Publicado: (2013)

Bax Contributes to Retinal Ganglion Cell Dendritic Degeneration During Glaucoma
por: Risner, Michael L., et al.
Publicado: (2022)

Neuroprotection by Wld(S) depends on retinal ganglion cell type and age in glaucoma
por: Risner, Michael L., et al.
Publicado: (2021)

Antioxidation and Cytoprotection of Acteoside and Its Derivatives: Comparison and Mechanistic Chemistry
por: Li, Xican, et al.
Publicado: (2018)

Protective Effect of Acteoside on Ovariectomy-Induced Bone Loss in Mice
por: Yang, Lingling, et al.
Publicado: (2019)

Design and Preparation of Molecularly Imprinted Membranes for Selective Separation of Acteoside
por: Zhao, Xiaobin, et al.
Publicado: (2020)

Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways
por: Lee, Kwanghyun, et al.
Publicado: (2022)

Overexpression of caveolin-1 reduces Taxol resistance in human osteosarcoma cells by attenuating PI3K-Akt-JNK dependent autophagy
por: Guan, Jian, et al.
Publicado: (2016)

Melatonin Repairs Osteoporotic Bone Defects in Iron-Overloaded Rats through PI3K/AKT/GSK-3β/P70S6k Signaling Pathway
por: Ren, Maoxian, et al.
Publicado: (2023)

Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma
por: Madeira, Maria H., et al.
Publicado: (2016)

Baicalin suppresses glaucoma pathogenesis by regulating the PI3K/AKT signaling in vitro and in vivo
por: Zhao, Ningmin, et al.
Publicado: (2021)

Acteoside and ursolic acid synergistically protects H(2)O(2)-induced neurotrosis by regulation of AKT/mTOR signalling: from network pharmacology to experimental validation
por: Qu, Yan-Jie, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nm1cvtp1s0jou8kbmkskecbfn7