Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices

[Image: see text] Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full inf...

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Autores principales: Ajdary, Rubina, Reyes, Guillermo, Kuula, Jani, Raussi-Lehto, Eija, Mikkola, Tomi S., Kankuri, Esko, Rojas, Orlando J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011395/
https://www.ncbi.nlm.nih.gov/pubmed/35445214
http://dx.doi.org/10.1021/acspolymersau.1c00045
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author Ajdary, Rubina
Reyes, Guillermo
Kuula, Jani
Raussi-Lehto, Eija
Mikkola, Tomi S.
Kankuri, Esko
Rojas, Orlando J.
author_facet Ajdary, Rubina
Reyes, Guillermo
Kuula, Jani
Raussi-Lehto, Eija
Mikkola, Tomi S.
Kankuri, Esko
Rojas, Orlando J.
author_sort Ajdary, Rubina
collection PubMed
description [Image: see text] Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.
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spelling pubmed-90113952022-04-18 Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices Ajdary, Rubina Reyes, Guillermo Kuula, Jani Raussi-Lehto, Eija Mikkola, Tomi S. Kankuri, Esko Rojas, Orlando J. ACS Polym Au [Image: see text] Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants. American Chemical Society 2021-12-10 /pmc/articles/PMC9011395/ /pubmed/35445214 http://dx.doi.org/10.1021/acspolymersau.1c00045 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Ajdary, Rubina
Reyes, Guillermo
Kuula, Jani
Raussi-Lehto, Eija
Mikkola, Tomi S.
Kankuri, Esko
Rojas, Orlando J.
Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices
title Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices
title_full Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices
title_fullStr Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices
title_full_unstemmed Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices
title_short Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices
title_sort direct ink writing of biocompatible nanocellulose and chitosan hydrogels for implant mesh matrices
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011395/
https://www.ncbi.nlm.nih.gov/pubmed/35445214
http://dx.doi.org/10.1021/acspolymersau.1c00045
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