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Antisense oligonucleotide: A promising therapeutic option to beat COVID‐19
The COVID‐19 crisis and the development of the first approved mRNA vaccine have highlighted the power of RNA‐based therapeutic strategies for the development of new medicines. Aside from RNA‐vaccines, antisense oligonucleotides (ASOs) represent a new and very promising class of RNA‐targeted therapy....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011570/ https://www.ncbi.nlm.nih.gov/pubmed/34842345 http://dx.doi.org/10.1002/wrna.1703 |
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author | Quemener, Anaïs M. Galibert, Marie‐Dominique |
author_facet | Quemener, Anaïs M. Galibert, Marie‐Dominique |
author_sort | Quemener, Anaïs M. |
collection | PubMed |
description | The COVID‐19 crisis and the development of the first approved mRNA vaccine have highlighted the power of RNA‐based therapeutic strategies for the development of new medicines. Aside from RNA‐vaccines, antisense oligonucleotides (ASOs) represent a new and very promising class of RNA‐targeted therapy. Few drugs have already received approval from the Food and Drug Administration. Here, we underscored why and how ASOs hold the potential to change the therapeutic landscape to beat SARS‐CoV‐2 viral infections. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule‐RNA Interactions. |
format | Online Article Text |
id | pubmed-9011570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90115702022-04-15 Antisense oligonucleotide: A promising therapeutic option to beat COVID‐19 Quemener, Anaïs M. Galibert, Marie‐Dominique Wiley Interdiscip Rev RNA Focus Article The COVID‐19 crisis and the development of the first approved mRNA vaccine have highlighted the power of RNA‐based therapeutic strategies for the development of new medicines. Aside from RNA‐vaccines, antisense oligonucleotides (ASOs) represent a new and very promising class of RNA‐targeted therapy. Few drugs have already received approval from the Food and Drug Administration. Here, we underscored why and how ASOs hold the potential to change the therapeutic landscape to beat SARS‐CoV‐2 viral infections. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule‐RNA Interactions. John Wiley & Sons, Inc. 2021-11-28 2022 /pmc/articles/PMC9011570/ /pubmed/34842345 http://dx.doi.org/10.1002/wrna.1703 Text en © 2021 The Authors. WIREs RNA published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Focus Article Quemener, Anaïs M. Galibert, Marie‐Dominique Antisense oligonucleotide: A promising therapeutic option to beat COVID‐19 |
title | Antisense oligonucleotide: A promising therapeutic option to beat COVID‐19 |
title_full | Antisense oligonucleotide: A promising therapeutic option to beat COVID‐19 |
title_fullStr | Antisense oligonucleotide: A promising therapeutic option to beat COVID‐19 |
title_full_unstemmed | Antisense oligonucleotide: A promising therapeutic option to beat COVID‐19 |
title_short | Antisense oligonucleotide: A promising therapeutic option to beat COVID‐19 |
title_sort | antisense oligonucleotide: a promising therapeutic option to beat covid‐19 |
topic | Focus Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011570/ https://www.ncbi.nlm.nih.gov/pubmed/34842345 http://dx.doi.org/10.1002/wrna.1703 |
work_keys_str_mv | AT quemeneranaism antisenseoligonucleotideapromisingtherapeuticoptiontobeatcovid19 AT galibertmariedominique antisenseoligonucleotideapromisingtherapeuticoptiontobeatcovid19 |