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Temporal relationship of myocarditis and pericarditis following COVID-19 vaccination: A pragmatic approach

BACKGROUND: Complications following COVID-19 vaccination, particularly with mRNA vaccines, rarely include myocarditis and pericarditis. This work principally aimed at defining a realistic temporal relationship between vaccination and myocarditis/pericarditis development. METHODS: All relevant cases...

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Autores principales: Anastassopoulou, Cleo, Hatziantoniou, Sophia, Vlachopoulos, Charalambos, Spanakis, Nicholas, Tsioufis, Costas, Tsakris, Athanasios, Lazaros, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011898/
https://www.ncbi.nlm.nih.gov/pubmed/35436559
http://dx.doi.org/10.1016/j.ijcard.2022.04.024
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author Anastassopoulou, Cleo
Hatziantoniou, Sophia
Vlachopoulos, Charalambos
Spanakis, Nicholas
Tsioufis, Costas
Tsakris, Athanasios
Lazaros, George
author_facet Anastassopoulou, Cleo
Hatziantoniou, Sophia
Vlachopoulos, Charalambos
Spanakis, Nicholas
Tsioufis, Costas
Tsakris, Athanasios
Lazaros, George
author_sort Anastassopoulou, Cleo
collection PubMed
description BACKGROUND: Complications following COVID-19 vaccination, particularly with mRNA vaccines, rarely include myocarditis and pericarditis. This work principally aimed at defining a realistic temporal relationship between vaccination and myocarditis/pericarditis development. METHODS: All relevant cases reported from week 52/2020 through week 41/2021 in the VAERS database were retrieved and analyzed for licensed vaccines. These included BNT162b2, mRNA-1273, and AD26.COV2·S. Incidence rates were calculated using the corresponding administered vaccine doses as denominators. Additionally, analyzed parameters included demographics, dose series, hospitalization length and outcome. RESULTS: Overall, 2016 myocarditis and 1380 pericarditis cases, (4.96/10(6) and 3.40/10(6) administered vaccine doses, respectively), were recorded. Most myocarditis cases occurred following BNT162b2 (5.60/10(6) doses) in males <30 years. Pericarditis affected predominantly males <40, both sexes >40 years, and was most common post AD26.COV2·S (4.78/10(6) doses). Hospitalization was required for 40.3% and 27.2% of myocarditis and pericarditis cases, respectively. A bimodal pattern was found for both myocarditis and pericarditis, with two peaks that coincided temporally, but were reversed in intensity. The first peak was recorded 1–3 days post-vaccination and was more pronounced in myocarditis, while the second was recorded 15–30 days post-vaccination and was more intense in pericarditis. CONCLUSIONS: Myocarditis/pericarditis after COVID-19 vaccination is rare and depicts a bimodal pattern.
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spelling pubmed-90118982022-04-18 Temporal relationship of myocarditis and pericarditis following COVID-19 vaccination: A pragmatic approach Anastassopoulou, Cleo Hatziantoniou, Sophia Vlachopoulos, Charalambos Spanakis, Nicholas Tsioufis, Costas Tsakris, Athanasios Lazaros, George Int J Cardiol Short Communication BACKGROUND: Complications following COVID-19 vaccination, particularly with mRNA vaccines, rarely include myocarditis and pericarditis. This work principally aimed at defining a realistic temporal relationship between vaccination and myocarditis/pericarditis development. METHODS: All relevant cases reported from week 52/2020 through week 41/2021 in the VAERS database were retrieved and analyzed for licensed vaccines. These included BNT162b2, mRNA-1273, and AD26.COV2·S. Incidence rates were calculated using the corresponding administered vaccine doses as denominators. Additionally, analyzed parameters included demographics, dose series, hospitalization length and outcome. RESULTS: Overall, 2016 myocarditis and 1380 pericarditis cases, (4.96/10(6) and 3.40/10(6) administered vaccine doses, respectively), were recorded. Most myocarditis cases occurred following BNT162b2 (5.60/10(6) doses) in males <30 years. Pericarditis affected predominantly males <40, both sexes >40 years, and was most common post AD26.COV2·S (4.78/10(6) doses). Hospitalization was required for 40.3% and 27.2% of myocarditis and pericarditis cases, respectively. A bimodal pattern was found for both myocarditis and pericarditis, with two peaks that coincided temporally, but were reversed in intensity. The first peak was recorded 1–3 days post-vaccination and was more pronounced in myocarditis, while the second was recorded 15–30 days post-vaccination and was more intense in pericarditis. CONCLUSIONS: Myocarditis/pericarditis after COVID-19 vaccination is rare and depicts a bimodal pattern. Elsevier B.V. 2022-07-01 2022-04-15 /pmc/articles/PMC9011898/ /pubmed/35436559 http://dx.doi.org/10.1016/j.ijcard.2022.04.024 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Anastassopoulou, Cleo
Hatziantoniou, Sophia
Vlachopoulos, Charalambos
Spanakis, Nicholas
Tsioufis, Costas
Tsakris, Athanasios
Lazaros, George
Temporal relationship of myocarditis and pericarditis following COVID-19 vaccination: A pragmatic approach
title Temporal relationship of myocarditis and pericarditis following COVID-19 vaccination: A pragmatic approach
title_full Temporal relationship of myocarditis and pericarditis following COVID-19 vaccination: A pragmatic approach
title_fullStr Temporal relationship of myocarditis and pericarditis following COVID-19 vaccination: A pragmatic approach
title_full_unstemmed Temporal relationship of myocarditis and pericarditis following COVID-19 vaccination: A pragmatic approach
title_short Temporal relationship of myocarditis and pericarditis following COVID-19 vaccination: A pragmatic approach
title_sort temporal relationship of myocarditis and pericarditis following covid-19 vaccination: a pragmatic approach
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011898/
https://www.ncbi.nlm.nih.gov/pubmed/35436559
http://dx.doi.org/10.1016/j.ijcard.2022.04.024
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