Are Dyskeratosis Congenita patients at higher risk of symptomatic COVID-19?

Dyskeratosis Congenita (DC) is a rare and heterogeneous disease. This disorder is resulted from a defect in the telomere maintenance in stem cells. Telomerase RNA component, shelterin complex, and telomerase reverse transcriptase are mutated in this disease. Many studies have previously confirmed sh...

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Autores principales: Dorgaleleh, Saeed, Naghipoor, Karim, Hozhabrpour, Amir, Vahidnezhad, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Letter to Editors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011900/
https://www.ncbi.nlm.nih.gov/pubmed/35464998
http://dx.doi.org/10.1016/j.mehy.2022.110843
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author Dorgaleleh, Saeed
Naghipoor, Karim
Hozhabrpour, Amir
Vahidnezhad, Hassan
author_facet Dorgaleleh, Saeed
Naghipoor, Karim
Hozhabrpour, Amir
Vahidnezhad, Hassan
author_sort Dorgaleleh, Saeed
collection PubMed
description Dyskeratosis Congenita (DC) is a rare and heterogeneous disease. This disorder is resulted from a defect in the telomere maintenance in stem cells. Telomerase RNA component, shelterin complex, and telomerase reverse transcriptase are mutated in this disease. Many studies have previously confirmed shorter leukocyte telomere length in DC. On the other hand, the association between telomere length and Coronavirus disease 2019 (COVID-19) indicated that people with a short telomere background mostly show more severe symptoms related to COVID-19, and the mortality rate among them increases as well. Because patients with DC have an abnormally short telomere length, in the current study, we hypothesized that they are at higher risk of developing symptomatic COVID-19 that requires further clinical care.
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spelling pubmed-90119002022-04-18 Are Dyskeratosis Congenita patients at higher risk of symptomatic COVID-19? Dorgaleleh, Saeed Naghipoor, Karim Hozhabrpour, Amir Vahidnezhad, Hassan Med Hypotheses Letter to Editors Dyskeratosis Congenita (DC) is a rare and heterogeneous disease. This disorder is resulted from a defect in the telomere maintenance in stem cells. Telomerase RNA component, shelterin complex, and telomerase reverse transcriptase are mutated in this disease. Many studies have previously confirmed shorter leukocyte telomere length in DC. On the other hand, the association between telomere length and Coronavirus disease 2019 (COVID-19) indicated that people with a short telomere background mostly show more severe symptoms related to COVID-19, and the mortality rate among them increases as well. Because patients with DC have an abnormally short telomere length, in the current study, we hypothesized that they are at higher risk of developing symptomatic COVID-19 that requires further clinical care. Elsevier Ltd. 2022-06 2022-04-15 /pmc/articles/PMC9011900/ /pubmed/35464998 http://dx.doi.org/10.1016/j.mehy.2022.110843 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to Editors
Dorgaleleh, Saeed
Naghipoor, Karim
Hozhabrpour, Amir
Vahidnezhad, Hassan
Are Dyskeratosis Congenita patients at higher risk of symptomatic COVID-19?
title Are Dyskeratosis Congenita patients at higher risk of symptomatic COVID-19?
title_full Are Dyskeratosis Congenita patients at higher risk of symptomatic COVID-19?
title_fullStr Are Dyskeratosis Congenita patients at higher risk of symptomatic COVID-19?
title_full_unstemmed Are Dyskeratosis Congenita patients at higher risk of symptomatic COVID-19?
title_short Are Dyskeratosis Congenita patients at higher risk of symptomatic COVID-19?
title_sort are dyskeratosis congenita patients at higher risk of symptomatic covid-19?
topic Letter to Editors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011900/
https://www.ncbi.nlm.nih.gov/pubmed/35464998
http://dx.doi.org/10.1016/j.mehy.2022.110843
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