Discovery of moiety preference by Shapley value in protein kinase family using random forest models

BACKGROUND: Human protein kinases play important roles in cancers, are highly co-regulated by kinase families rather than a single kinase, and complementarily regulate signaling pathways. Even though there are > 100,000 protein kinase inhibitors, only 67 kinase drugs are currently approved by the...

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Detalles Bibliográficos
Autores principales: Huang, Yu-Wei, Hsu, Yen-Chao, Chuang, Yi-Hsuan, Chen, Yun-Ti, Lin, Xiang-Yu, Fan, You-Wei, Pathak, Nikhil, Yang, Jinn-Moon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011936/
https://www.ncbi.nlm.nih.gov/pubmed/35428180
http://dx.doi.org/10.1186/s12859-022-04663-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011936/
https://www.ncbi.nlm.nih.gov/pubmed/35428180
http://dx.doi.org/10.1186/s12859-022-04663-5

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