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Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs)

BACKGROUND: Genomic instability and chemoresistance can arise in cancer due to a unique form of plasticity: that of polyploid giant cancer cells (PGCCs). These cells form under the stress of chemotherapy and have higher than diploid chromosome content. PGCCs are able to then repopulate tumors throug...

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Detalles Bibliográficos
Autores principales:	Bowers, Robert R., Andrade, Maya F., Jones, Christian M., White-Gilbertson, Shai, Voelkel-Johnson, Christina, Delaney, Joe R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012005/ https://www.ncbi.nlm.nih.gov/pubmed/35421971 http://dx.doi.org/10.1186/s12885-022-09503-6

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