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TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages

TPL-2 kinase plays an important role in innate immunity, activating ERK1/2 MAPKs in myeloid cells following TLR stimulation. We investigated how TPL-2 controls transcription in TLR4-stimulated mouse macrophages. TPL-2 activation of ERK1/2 regulated expression of genes encoding transcription factors,...

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Detalles Bibliográficos
Autores principales:	Blair, Louise, Pattison, Michael J., Chakravarty, Probir, Papoutsopoulou, Stamatia, Bakiri, Latifa, Wagner, Erwin F., Smale, Stephen, Ley, Steven C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2022
Materias:	Innate Immunity and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012084/ https://www.ncbi.nlm.nih.gov/pubmed/35082159 http://dx.doi.org/10.4049/jimmunol.2100213

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