Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence

Mice with experimental nerve damage can display long‑lasting neuropathic pain behavior. We show here that 4 months and later after nerve injury, male but not female mice displayed telomere length (TL) reduction and p53‑mediated cellular senescence in the spinal cord, resulting in maintenance of pain...

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Detalles Bibliográficos
Autores principales: Muralidharan, Arjun, Sotocinal, Susana G., Yousefpour, Noosha, Akkurt, Nur, Lima, Lucas V., Tansley, Shannon, Parisien, Marc, Wang, Chengyang, Austin, Jean-Sebastien, Ham, Boram, Dutra, Gabrielle M.G.S., Rousseau, Philippe, Maldonado-Bouchard, Sioui, Clark, Teleri, Rosen, Sarah F., Majeed, Mariam R., Silva, Olivia, Nejade, Rachel, Li, Xinyu, Donayre Pimentel, Stephania, Nielsen, Christopher S., Neely, G. Gregory, Autexier, Chantal, Diatchenko, Luda, Ribeiro-da-Silva, Alfredo, Mogil, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012275/
https://www.ncbi.nlm.nih.gov/pubmed/35426375
http://dx.doi.org/10.1172/JCI151817

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