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CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis

Cerebral autosomal dominant arteriopathy, subcortical infarcts, and leukoencephalopathy (CADASIL) is the most common monogenic form of small vessel disease characterized by migraine with aura, leukoaraiosis, strokes, and dementia. CADASIL mutations cause cerebrovascular dysfunction in both animal mo...

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Detalles Bibliográficos
Autores principales:	Oka, Fumiaki, Lee, Jeong Hyun, Yuzawa, Izumi, Li, Mei, von Bornstaedt, Daniel, Eikermann-Haerter, Katharina, Qin, Tao, Chung, David Y., Sadeghian, Homa, Seidel, Jessica L., Imai, Takahiko, Vuralli, Doga, Platt, Rosangela M., Nelson, Mark T., Joutel, Anne, Sakadzic, Sava, Ayata, Cenk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012276/ https://www.ncbi.nlm.nih.gov/pubmed/35202003 http://dx.doi.org/10.1172/JCI149759

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