Intrahepatic microbes govern liver immunity by programming NKT cells

The gut microbiome shapes local and systemic immunity. The liver is presumed to be a protected sterile site. As such, a hepatic microbiome has not been examined. Here, we showed a liver microbiome in mice and humans that is distinct from that of the gut and is enriched in Proteobacteria. It undergoe...

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Detalles Bibliográficos
Autores principales: Leinwand, Joshua C., Paul, Bidisha, Chen, Ruonan, Xu, Fangxi, Sierra, Maria A., Paluru, Madan M., Nanduri, Sumant, Alcantara, Carolina G., Shadaloey, Sorin A.A., Yang, Fan, Adam, Salma A., Li, Qianhao, Bandel, Michelle, Gakhal, Inderdeep, Appiah, Lara, Guo, Yuqi, Vardhan, Mridula, Flaminio, Zia, Grodman, Emilie R., Mermelstein, Ari, Wang, Wei, Diskin, Brian, Aykut, Berk, Khan, Mohammad, Werba, Gregor, Pushalkar, Smruti, McKinstry, Mia, Kluger, Zachary, Park, Jaimie J., Hsieh, Brandon, Dancel-Manning, Kristen, Liang, Feng-Xia, Park, James S., Saxena, Anjana, Li, Xin, Theise, Neil D., Saxena, Deepak, Miller, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012289/
https://www.ncbi.nlm.nih.gov/pubmed/35175938
http://dx.doi.org/10.1172/JCI151725

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