Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1–mediated tumor eradication

Collagens in the extracellular matrix (ECM) provide a physical barrier to tumor immune infiltration, while also acting as a ligand for immune inhibitory receptors. Transforming growth factor-β (TGF-β) is a key contributor to shaping the ECM by stimulating the production and remodeling of collagens....

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Detalles Bibliográficos
Autores principales: Horn, Lucas A., Chariou, Paul L., Gameiro, Sofia R., Qin, Haiyan, Iida, Masafumi, Fousek, Kristen, Meyer, Thomas J., Cam, Margaret, Flies, Dallas, Langermann, Solomon, Schlom, Jeffrey, Palena, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012291/
https://www.ncbi.nlm.nih.gov/pubmed/35230974
http://dx.doi.org/10.1172/JCI155148

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