Design, Synthesis, and Biological Evaluation of 2-Anilino-4-Triazolpyrimidine Derivatives as CDK4/HDACs Inhibitors

PURPOSE: To enhance the cytotoxicities of our obtained CDK4 inhibitors and get CDK4/HDACs inhibitors with potent enzymatic inhibitory and anti-proliferative activities. METHODS: A series of novel CDK4/HDACs inhibitors were designed and synthesized by incorporating the HDAC pharmacophores (hydroxylam...

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Detalles Bibliográficos
Autores principales: Wang, Suhua, Han, Siyuan, Cheng, Weiyan, Miao, Ruoyang, Li, Shasha, Tian, Xin, Kan, Quancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012344/
https://www.ncbi.nlm.nih.gov/pubmed/35431540
http://dx.doi.org/10.2147/DDDT.S351049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012344/
https://www.ncbi.nlm.nih.gov/pubmed/35431540
http://dx.doi.org/10.2147/DDDT.S351049

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