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Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models

PURPOSE: The blood–brain barrier (BBB) inhibits adequate dosing/penetration of therapeutic agents to malignancies in the brain. Low-intensity pulsed ultrasound (LIPU) is a safe therapeutic method of temporary BBB disruption (BBBD) to enhance chemotherapeutic delivery to the tumor and surrounding bra...

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Detalles Bibliográficos
Autores principales: Sabbagh, Aria, Beccaria, Kevin, Ling, Xiaoyang, Marisetty, Anantha, Ott, Martina, Caruso, Hillary, Barton, Emily, Kong, Ling-Yuan, Fang, Dexing, Latha, Khatri, Zhang, Daniel Yang, Wei, Jun, DeGroot, John, Curran, Michael A., Rao, Ganesh, Hu, Jian, Desseaux, Carole, Bouchoux, Guillaume, Canney, Michael, Carpentier, Alexandre, Heimberger, Amy B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012394/
https://www.ncbi.nlm.nih.gov/pubmed/34031054
http://dx.doi.org/10.1158/1078-0432.CCR-20-3760