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Theory of defect-mediated morphogenesis
Growing experimental evidence indicates that topological defects could serve as organizing centers in the morphogenesis of tissues. Here, we provide a quantitative explanation for this phenomenon, rooted in the buckling theory of deformable active polar liquid crystals. Using a combination of linear...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012457/ https://www.ncbi.nlm.nih.gov/pubmed/35427161 http://dx.doi.org/10.1126/sciadv.abk2712 |
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author | Hoffmann, Ludwig A. Carenza, Livio Nicola Eckert, Julia Giomi, Luca |
author_facet | Hoffmann, Ludwig A. Carenza, Livio Nicola Eckert, Julia Giomi, Luca |
author_sort | Hoffmann, Ludwig A. |
collection | PubMed |
description | Growing experimental evidence indicates that topological defects could serve as organizing centers in the morphogenesis of tissues. Here, we provide a quantitative explanation for this phenomenon, rooted in the buckling theory of deformable active polar liquid crystals. Using a combination of linear stability analysis and computational fluid dynamics, we demonstrate that active layers, such as confined cell monolayers, are unstable to the formation of protrusions in the presence of disclinations. The instability originates from an interplay between the focusing of the elastic forces, mediated by defects, and the renormalization of the system’s surface tension by the active flow. The posttransitional regime is also characterized by several complex morphodynamical processes, such as oscillatory deformations, droplet nucleation, and active turbulence. Our findings offer an explanation of recent observations on tissue morphogenesis and shed light on the dynamics of active surfaces in general. |
format | Online Article Text |
id | pubmed-9012457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-90124572022-04-26 Theory of defect-mediated morphogenesis Hoffmann, Ludwig A. Carenza, Livio Nicola Eckert, Julia Giomi, Luca Sci Adv Physical and Materials Sciences Growing experimental evidence indicates that topological defects could serve as organizing centers in the morphogenesis of tissues. Here, we provide a quantitative explanation for this phenomenon, rooted in the buckling theory of deformable active polar liquid crystals. Using a combination of linear stability analysis and computational fluid dynamics, we demonstrate that active layers, such as confined cell monolayers, are unstable to the formation of protrusions in the presence of disclinations. The instability originates from an interplay between the focusing of the elastic forces, mediated by defects, and the renormalization of the system’s surface tension by the active flow. The posttransitional regime is also characterized by several complex morphodynamical processes, such as oscillatory deformations, droplet nucleation, and active turbulence. Our findings offer an explanation of recent observations on tissue morphogenesis and shed light on the dynamics of active surfaces in general. American Association for the Advancement of Science 2022-04-15 /pmc/articles/PMC9012457/ /pubmed/35427161 http://dx.doi.org/10.1126/sciadv.abk2712 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Physical and Materials Sciences Hoffmann, Ludwig A. Carenza, Livio Nicola Eckert, Julia Giomi, Luca Theory of defect-mediated morphogenesis |
title | Theory of defect-mediated morphogenesis |
title_full | Theory of defect-mediated morphogenesis |
title_fullStr | Theory of defect-mediated morphogenesis |
title_full_unstemmed | Theory of defect-mediated morphogenesis |
title_short | Theory of defect-mediated morphogenesis |
title_sort | theory of defect-mediated morphogenesis |
topic | Physical and Materials Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012457/ https://www.ncbi.nlm.nih.gov/pubmed/35427161 http://dx.doi.org/10.1126/sciadv.abk2712 |
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