Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration

Genetic CLN5 variants are associated with childhood neurodegeneration and Alzheimer’s disease; however, the molecular function of ceroid lipofuscinosis neuronal protein 5 (Cln5) is unknown. We solved the Cln5 crystal structure and identified a region homologous to the catalytic domain of members of...

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Detalles Bibliográficos
Autores principales: Luebben, Anna V., Bender, Daniel, Becker, Stefan, Crowther, Lisa M., Erven, Ilka, Hofmann, Kay, Söding, Johannes, Klemp, Henry, Bellotti, Cristina, Stäuble, Andreas, Qiu, Tian, Kathayat, Rahul S., Dickinson, Bryan C., Gärtner, Jutta, Sheldrick, George M., Krätzner, Ralph, Steinfeld, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012467/
https://www.ncbi.nlm.nih.gov/pubmed/35427157
http://dx.doi.org/10.1126/sciadv.abj8633

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