Tracing brain genotoxic stress in Parkinson’s disease with a novel single-cell genetic sensor

To develop an in vivo tool to probe brain genotoxic stress, we designed a viral proxy as a single-cell genetic sensor termed PRISM that harnesses the instability of recombinant adeno-associated virus genome processing and a hypermutable repeat sequence–dependent reporter. PRISM exploits the virus-ho...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Saadi, Madison Wynne, Tian, Xinli, Grames, Mychal, Ren, Michael, Keys, Kelsea, Li, Hanna, Knott, Erika, Yin, Hong, Huang, Shile, Lu, Xiao-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012470/
https://www.ncbi.nlm.nih.gov/pubmed/35427151
http://dx.doi.org/10.1126/sciadv.abd1700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012470/
https://www.ncbi.nlm.nih.gov/pubmed/35427151
http://dx.doi.org/10.1126/sciadv.abd1700

Ejemplares similares