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Deconditioning in COVID-19 survivors with reduced exercise performance: A role for endothelial dysfunction?

Recent studies have reported an impaired exercise response at cardiopulmonary exercise testing (CPET) during convalescence from coronavirus disease 2019 (COVID-19). In detail, these previous reports suggest the presence of functional limitations in a consistent proportion of COVID-19 survivors, in t...

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Detalles Bibliográficos
Autores principales: Ambrosino, Pasquale, Maniscalco, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012505/
https://www.ncbi.nlm.nih.gov/pubmed/35464997
http://dx.doi.org/10.1016/j.mehy.2022.110847
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author Ambrosino, Pasquale
Maniscalco, Mauro
author_facet Ambrosino, Pasquale
Maniscalco, Mauro
author_sort Ambrosino, Pasquale
collection PubMed
description Recent studies have reported an impaired exercise response at cardiopulmonary exercise testing (CPET) during convalescence from coronavirus disease 2019 (COVID-19). In detail, these previous reports suggest the presence of functional limitations in a consistent proportion of COVID-19 survivors, in the absence of relevant alterations of ventilatory and gas exchange parameters at CPET. Therefore, deconditioning has been proposed as the main mechanism of the reduced peak oxygen uptake in this clinical setting. This interpretation of the results is supported by the evidence that deconditioning is a recognized aspect of the post-intensive care syndrome, with acute sarcopenia being frequently observed among COVID-19 survivors. Here, we hypothesized the role of endothelial dysfunction as a key pathogenic mechanism of the functional limitations of COVID-19, including multisystem deconditioning and subsequent exercise intolerance.
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spelling pubmed-90125052022-04-18 Deconditioning in COVID-19 survivors with reduced exercise performance: A role for endothelial dysfunction? Ambrosino, Pasquale Maniscalco, Mauro Med Hypotheses Correspondence Recent studies have reported an impaired exercise response at cardiopulmonary exercise testing (CPET) during convalescence from coronavirus disease 2019 (COVID-19). In detail, these previous reports suggest the presence of functional limitations in a consistent proportion of COVID-19 survivors, in the absence of relevant alterations of ventilatory and gas exchange parameters at CPET. Therefore, deconditioning has been proposed as the main mechanism of the reduced peak oxygen uptake in this clinical setting. This interpretation of the results is supported by the evidence that deconditioning is a recognized aspect of the post-intensive care syndrome, with acute sarcopenia being frequently observed among COVID-19 survivors. Here, we hypothesized the role of endothelial dysfunction as a key pathogenic mechanism of the functional limitations of COVID-19, including multisystem deconditioning and subsequent exercise intolerance. Published by Elsevier Ltd. 2022-06 2022-04-15 /pmc/articles/PMC9012505/ /pubmed/35464997 http://dx.doi.org/10.1016/j.mehy.2022.110847 Text en © 2022 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Correspondence
Ambrosino, Pasquale
Maniscalco, Mauro
Deconditioning in COVID-19 survivors with reduced exercise performance: A role for endothelial dysfunction?
title Deconditioning in COVID-19 survivors with reduced exercise performance: A role for endothelial dysfunction?
title_full Deconditioning in COVID-19 survivors with reduced exercise performance: A role for endothelial dysfunction?
title_fullStr Deconditioning in COVID-19 survivors with reduced exercise performance: A role for endothelial dysfunction?
title_full_unstemmed Deconditioning in COVID-19 survivors with reduced exercise performance: A role for endothelial dysfunction?
title_short Deconditioning in COVID-19 survivors with reduced exercise performance: A role for endothelial dysfunction?
title_sort deconditioning in covid-19 survivors with reduced exercise performance: a role for endothelial dysfunction?
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012505/
https://www.ncbi.nlm.nih.gov/pubmed/35464997
http://dx.doi.org/10.1016/j.mehy.2022.110847
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