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Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl

An inflammatory myofibroblastic tumor (IMT) is an uncommon, benign tumor of myofibroblastic spindle cells. An IMT can occur in any part of the body. However, involving kidney is exceedingly rare. When this rare entity occurs in children, it becomes incredibly challenging to distinguish this rare ent...

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Autores principales: Tareen, Bisma, Faith, Hayden, Waheed, Abdul, Ullah, Asad, Kavuri, Sravan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012594/
https://www.ncbi.nlm.nih.gov/pubmed/35449656
http://dx.doi.org/10.7759/cureus.23289
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author Tareen, Bisma
Faith, Hayden
Waheed, Abdul
Ullah, Asad
Kavuri, Sravan K
author_facet Tareen, Bisma
Faith, Hayden
Waheed, Abdul
Ullah, Asad
Kavuri, Sravan K
author_sort Tareen, Bisma
collection PubMed
description An inflammatory myofibroblastic tumor (IMT) is an uncommon, benign tumor of myofibroblastic spindle cells. An IMT can occur in any part of the body. However, involving kidney is exceedingly rare. When this rare entity occurs in children, it becomes incredibly challenging to distinguish this rare entity from other malignancies such as Wilms tumor. Although imaging studies of the abdomen and pelvis add to the diagnosis, however, histological examination and immunohistochemical staining remain the gold standard for the precise diagnosis of this rare entity. To the best of our knowledge, only 48 cases of renal IMT have been published in the medical literature so far. We report the case of a nine-month-old girl who was brought with complaints of hematuria, and later, imaging and histological confirmation revealed an anaplastic lymphoma kinase (ALK)-negative IMT of the kidney.
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spelling pubmed-90125942022-04-20 Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl Tareen, Bisma Faith, Hayden Waheed, Abdul Ullah, Asad Kavuri, Sravan K Cureus Pathology An inflammatory myofibroblastic tumor (IMT) is an uncommon, benign tumor of myofibroblastic spindle cells. An IMT can occur in any part of the body. However, involving kidney is exceedingly rare. When this rare entity occurs in children, it becomes incredibly challenging to distinguish this rare entity from other malignancies such as Wilms tumor. Although imaging studies of the abdomen and pelvis add to the diagnosis, however, histological examination and immunohistochemical staining remain the gold standard for the precise diagnosis of this rare entity. To the best of our knowledge, only 48 cases of renal IMT have been published in the medical literature so far. We report the case of a nine-month-old girl who was brought with complaints of hematuria, and later, imaging and histological confirmation revealed an anaplastic lymphoma kinase (ALK)-negative IMT of the kidney. Cureus 2022-03-18 /pmc/articles/PMC9012594/ /pubmed/35449656 http://dx.doi.org/10.7759/cureus.23289 Text en Copyright © 2022, Tareen et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Tareen, Bisma
Faith, Hayden
Waheed, Abdul
Ullah, Asad
Kavuri, Sravan K
Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl
title Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl
title_full Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl
title_fullStr Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl
title_full_unstemmed Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl
title_short Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl
title_sort anaplastic lymphoma kinase (alk)-negative inflammatory myofibroblastic tumor of the kidney in a nine-month-old girl
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012594/
https://www.ncbi.nlm.nih.gov/pubmed/35449656
http://dx.doi.org/10.7759/cureus.23289
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