Diffuse Large B-cell Lymphoma of the Tibia in a Patient With Longstanding Seropositive Rheumatoid Arthritis on Methotrexate

There has been an observance of increased occurrence of malignant lymphomas in patients with rheumatoid arthritis (RA). The increased risk of lymphoproliferative disorders has been linked to the severity of RA disease activity, the use of disease-modifying agents like methotrexate and certain geneti...

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Autores principales: Oberoi, Mansi, Perinkulam Sathyanarayanan, Swaminathan, Akther, Jacky, Tantoush, Hamza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012651/
https://www.ncbi.nlm.nih.gov/pubmed/35449681
http://dx.doi.org/10.7759/cureus.23232
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author Oberoi, Mansi
Perinkulam Sathyanarayanan, Swaminathan
Akther, Jacky
Tantoush, Hamza
author_facet Oberoi, Mansi
Perinkulam Sathyanarayanan, Swaminathan
Akther, Jacky
Tantoush, Hamza
author_sort Oberoi, Mansi
collection PubMed
description There has been an observance of increased occurrence of malignant lymphomas in patients with rheumatoid arthritis (RA). The increased risk of lymphoproliferative disorders has been linked to the severity of RA disease activity, the use of disease-modifying agents like methotrexate and certain genetic links between RA and lymphomas. This article outlines the case of an 88-year-old gentleman with a 13-year history of seropositive rheumatoid arthritis on methotrexate who presented with ankle pain and was subsequently found to have diffuse large B-cell lymphoma on further workup.
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spelling pubmed-90126512022-04-20 Diffuse Large B-cell Lymphoma of the Tibia in a Patient With Longstanding Seropositive Rheumatoid Arthritis on Methotrexate Oberoi, Mansi Perinkulam Sathyanarayanan, Swaminathan Akther, Jacky Tantoush, Hamza Cureus Internal Medicine There has been an observance of increased occurrence of malignant lymphomas in patients with rheumatoid arthritis (RA). The increased risk of lymphoproliferative disorders has been linked to the severity of RA disease activity, the use of disease-modifying agents like methotrexate and certain genetic links between RA and lymphomas. This article outlines the case of an 88-year-old gentleman with a 13-year history of seropositive rheumatoid arthritis on methotrexate who presented with ankle pain and was subsequently found to have diffuse large B-cell lymphoma on further workup. Cureus 2022-03-16 /pmc/articles/PMC9012651/ /pubmed/35449681 http://dx.doi.org/10.7759/cureus.23232 Text en Copyright © 2022, Oberoi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Oberoi, Mansi
Perinkulam Sathyanarayanan, Swaminathan
Akther, Jacky
Tantoush, Hamza
Diffuse Large B-cell Lymphoma of the Tibia in a Patient With Longstanding Seropositive Rheumatoid Arthritis on Methotrexate
title Diffuse Large B-cell Lymphoma of the Tibia in a Patient With Longstanding Seropositive Rheumatoid Arthritis on Methotrexate
title_full Diffuse Large B-cell Lymphoma of the Tibia in a Patient With Longstanding Seropositive Rheumatoid Arthritis on Methotrexate
title_fullStr Diffuse Large B-cell Lymphoma of the Tibia in a Patient With Longstanding Seropositive Rheumatoid Arthritis on Methotrexate
title_full_unstemmed Diffuse Large B-cell Lymphoma of the Tibia in a Patient With Longstanding Seropositive Rheumatoid Arthritis on Methotrexate
title_short Diffuse Large B-cell Lymphoma of the Tibia in a Patient With Longstanding Seropositive Rheumatoid Arthritis on Methotrexate
title_sort diffuse large b-cell lymphoma of the tibia in a patient with longstanding seropositive rheumatoid arthritis on methotrexate
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012651/
https://www.ncbi.nlm.nih.gov/pubmed/35449681
http://dx.doi.org/10.7759/cureus.23232
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AT aktherjacky diffuselargebcelllymphomaofthetibiainapatientwithlongstandingseropositiverheumatoidarthritisonmethotrexate
AT tantoushhamza diffuselargebcelllymphomaofthetibiainapatientwithlongstandingseropositiverheumatoidarthritisonmethotrexate

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