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Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop

Genetic mutations in pancreatic digestive enzymes may cause protein misfolding, endoplasmic reticulum (ER) stress and chronic pancreatitis. The CPA1 N256K mouse model carries the human p.N256K carboxypeptidase A1 (CPA1) mutation, a classic example of a pancreatitis-associated misfolding variant. CPA...

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Detalles Bibliográficos
Autores principales:	Németh, Balázs Csaba, Demcsák, Alexandra, Geisz, Andrea, Sahin-Tóth, Miklós
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012826/ https://www.ncbi.nlm.nih.gov/pubmed/35428786 http://dx.doi.org/10.1038/s41598-022-09595-x

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