SIRT1 restoration enhances chondrocyte autophagy in osteoarthritis through PTEN-mediated EGFR ubiquitination

The pharmacological interventions aimed at activating pathways inducing chondrocyte autophagy or reversing extracellular matrix degradation may be promising approaches for the management of osteoarthritis (OA). Evidence exists suggesting that sirtuin 1 (SIRT1) is involved in the pathogenesis of OA....

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Detalles Bibliográficos
Autores principales: Lu, Qunshan, Liu, Peilai, Miao, Zhuang, Luo, Desu, Li, Songlin, Lu, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012846/
https://www.ncbi.nlm.nih.gov/pubmed/35428355
http://dx.doi.org/10.1038/s41420-022-00896-8

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