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A quantitative approach to the spread of variance in translational research using Monte Carlo simulation
The translation of promising preclinical research into successful trials often fails. One contributing factor is the “Princess and the Pea” problem, which refers to how an initially significant effect size dissipates as research transitions to more complex systems. This work aimed to quantify the ef...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012853/ https://www.ncbi.nlm.nih.gov/pubmed/35428790 http://dx.doi.org/10.1038/s41598-022-09921-3 |