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Alignment of PrEP use and sexual behavior over four months among men who have sex with men in the southern United States

Unlike antiretrovirals for HIV treatment, pre-exposure prophylaxis (PrEP) does not require continual adherence to be fully effective; rather, PrEP adherence is important only in the context of episodes of sexual risk. Therefore, studies of PrEP adherence and persistence must incorporate contemporane...

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Autores principales: Jones, Jeb, Pampati, Sanjana, Siegler, Aaron J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012906/
https://www.ncbi.nlm.nih.gov/pubmed/35429308
http://dx.doi.org/10.1007/s10461-022-03685-7
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author Jones, Jeb
Pampati, Sanjana
Siegler, Aaron J.
author_facet Jones, Jeb
Pampati, Sanjana
Siegler, Aaron J.
author_sort Jones, Jeb
collection PubMed
description Unlike antiretrovirals for HIV treatment, pre-exposure prophylaxis (PrEP) does not require continual adherence to be fully effective; rather, PrEP adherence is important only in the context of episodes of sexual risk. Therefore, studies of PrEP adherence and persistence must incorporate contemporaneous measurement of sexual behavior. Short, frequent surveys of PrEP use and sexual behavior allow for the measurement of the alignment between PrEP use and sexual behavior. We assessed the feasibility of using biweekly PrEP use and sexual behavior questionnaires to measure adherence and persistence on PrEP over a period of four months. We also measured the alignment of PrEP use and condomless anal sex. PrEP-using MSM in the southern US were recruited using online advertisements. Participants completed a baseline survey followed by brief surveys every two weeks for 16 weeks to report their PrEP use and sexual behavior over the preceding two-week period. Study retention was high: 91% of participants completed the baseline and final survey and, overall, 86% of study surveys were completed. Self-reported PrEP adherence and persistence were high, but instances of PrEP non-adherence were observed to frequently overlap with episodes of condomless anal sex. The most prominent reasons cited for missing PrEP doses were being too busy, not having PrEP on hand, and not being sexually active. Completing short, biweekly surveys of PrEP use and sexual behavior is feasible and acceptable to MSM in the southern US. Future studies should investigate incorporating biomarker measurements to validate self-reported adherence.
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spelling pubmed-90129062022-04-18 Alignment of PrEP use and sexual behavior over four months among men who have sex with men in the southern United States Jones, Jeb Pampati, Sanjana Siegler, Aaron J. AIDS Behav Original Paper Unlike antiretrovirals for HIV treatment, pre-exposure prophylaxis (PrEP) does not require continual adherence to be fully effective; rather, PrEP adherence is important only in the context of episodes of sexual risk. Therefore, studies of PrEP adherence and persistence must incorporate contemporaneous measurement of sexual behavior. Short, frequent surveys of PrEP use and sexual behavior allow for the measurement of the alignment between PrEP use and sexual behavior. We assessed the feasibility of using biweekly PrEP use and sexual behavior questionnaires to measure adherence and persistence on PrEP over a period of four months. We also measured the alignment of PrEP use and condomless anal sex. PrEP-using MSM in the southern US were recruited using online advertisements. Participants completed a baseline survey followed by brief surveys every two weeks for 16 weeks to report their PrEP use and sexual behavior over the preceding two-week period. Study retention was high: 91% of participants completed the baseline and final survey and, overall, 86% of study surveys were completed. Self-reported PrEP adherence and persistence were high, but instances of PrEP non-adherence were observed to frequently overlap with episodes of condomless anal sex. The most prominent reasons cited for missing PrEP doses were being too busy, not having PrEP on hand, and not being sexually active. Completing short, biweekly surveys of PrEP use and sexual behavior is feasible and acceptable to MSM in the southern US. Future studies should investigate incorporating biomarker measurements to validate self-reported adherence. Springer US 2022-04-16 2022 /pmc/articles/PMC9012906/ /pubmed/35429308 http://dx.doi.org/10.1007/s10461-022-03685-7 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Jones, Jeb
Pampati, Sanjana
Siegler, Aaron J.
Alignment of PrEP use and sexual behavior over four months among men who have sex with men in the southern United States
title Alignment of PrEP use and sexual behavior over four months among men who have sex with men in the southern United States
title_full Alignment of PrEP use and sexual behavior over four months among men who have sex with men in the southern United States
title_fullStr Alignment of PrEP use and sexual behavior over four months among men who have sex with men in the southern United States
title_full_unstemmed Alignment of PrEP use and sexual behavior over four months among men who have sex with men in the southern United States
title_short Alignment of PrEP use and sexual behavior over four months among men who have sex with men in the southern United States
title_sort alignment of prep use and sexual behavior over four months among men who have sex with men in the southern united states
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012906/
https://www.ncbi.nlm.nih.gov/pubmed/35429308
http://dx.doi.org/10.1007/s10461-022-03685-7
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