Cargando…

Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model

Detalles Bibliográficos
Autores principales:	Zhang, Ruxue, Zhang, Yumin, Zheng, Wei, Shang, Weijuan, Wu, Yan, Li, Ning, Xiong, Jun, Jiang, Hualiang, Shen, Jingshan, Xiao, Gengfu, Xie, Yuanchao, Zhang, Leike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012943/ https://www.ncbi.nlm.nih.gov/pubmed/35429988 http://dx.doi.org/10.1038/s41392-022-00963-7

Ejemplares similares

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2
por: Xie, Yuanchao, et al.
Publicado: (2021)

A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir
por: Zhang, Yumin, et al.
Publicado: (2023)

VV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19
por: Cao, Zhujun, et al.
Publicado: (2022)

Comprehensive interactome analysis of the spike protein of swine acute diarrhea syndrome coronavirus
por: Wang, Qingxing, et al.
Publicado: (2021)

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease
por: Su, Haixia, et al.
Publicado: (2021)

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
por: Wang, Manli, et al.
Publicado: (2020)

Practical and Highly Efficient Synthesis of Remdesivir from GS-441524
por: Hu, Tianwen, et al.
Publicado: (2022)

Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects
por: Qian, Hong-jie, et al.
Publicado: (2022)

An open, prospective cohort study of VV116 in Chinese participants infected with SARS-CoV-2 omicron variants
por: Shen, Yinzhong, et al.
Publicado: (2022)

The safety and efficacy of oral antiviral drug VV116 for treatment of COVID-19: A systematic review
por: Xiao, Ningkun, et al.
Publicado: (2023)

Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir
por: Jiang, Xiangrui, et al.
Publicado: (2023)

Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC–MS/MS
por: Hu, Wenjuan, et al.
Publicado: (2021)

Characterization of in-vivo human metabolites of the oral nucleoside anti-COVID-19 drug VV116 using UHPLC-Orbitrap-MS
por: Zhou, Ainan, et al.
Publicado: (2023)

VvMYB14 participates in melatonin-induced proanthocyanidin biosynthesis by upregulating expression of VvMYBPA1 and VvMYBPA2 in grape seeds
por: Zhang, Xiaoqian, et al.
Publicado: (2022)

Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and β-d-N(4)-hydroxycytidine
por: Xie, Yuanchao, et al.
Publicado: (2021)

Visualizing lymphocytic choriomeningitis virus infection in cells and living mice
por: Wen, Yuxi, et al.
Publicado: (2022)

Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs
por: Zheng, Wei, et al.
Publicado: (2022)

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
por: Xiong, Rui, et al.
Publicado: (2020)

V.V. Maiakovski /
Publicado: (1986)

A Comparative Quantitative Proteomic Analysis of HCMV-Infected Cells Highlights pUL138 as a Multifunctional Protein
por: Li, Yang, et al.
Publicado: (2020)

Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
por: Xiong, Rui, et al.
Publicado: (2020)

Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
por: Xiong, Rui, et al.
Publicado: (2020)

Development of horse neutralizing immunoglobulin and immunoglobulin fragments against Junín virus
por: Pan, Xiaoyan, et al.
Publicado: (2020)

Immunoglobulin fragment F(ab’)(2) against RBD potently neutralizes SARS-CoV-2 in vitro
por: Pan, Xiaoyan, et al.
Publicado: (2020)

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
por: Gordon, Calvin J., et al.
Publicado: (2020)

In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2
por: Shang, Weijuan, et al.
Publicado: (2022)

M3, a natural lignan xyloside, exhibits potent anticancer activity in HCT116 cells
por: Shen, Weidong, et al.
Publicado: (2019)

Interleukin 1 and interleukin 1 inhibitor production by human macrophages exposed to influenza virus or respiratory syncytial virus. Respiratory syncytial virus is a potent inducer of inhibitor activity
Publicado: (1986)

ATLAS Searches for VV Resonances
por: Lin, Chiao-ying
Publicado: (2019)

ATLAS Searches for $VV$ Resonances
por: Les, Robert
Publicado: (2019)

Charmless $B \to VV$ decays
por: Romero Vidal, A
Publicado: (2013)

Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus
por: Wang, Qingxing, et al.
Publicado: (2021)

VvMYB15 and VvWRKY40 Positively Co-regulated Anthocyanin Biosynthesis in Grape Berries in Response to Root Restriction
por: Li, Dongmei, et al.
Publicado: (2021)

Discovery of a Series of Potent and Selective Nucleotide Prodrug Inhibitors of Respiratory Syncytial Virus (RSV) Replication
por: Good, Steven, et al.
Publicado: (2017)

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus
por: Marcandalli, Jessica, et al.
Publicado: (2019)

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
por: Rossey, Iebe, et al.
Publicado: (2017)

Respiratory Syncytial Virus
por: Fraire, Armando E., et al.
Publicado: (2013)

Respiratory syncytial virus
por: Ruuskanen, Olli, et al.
Publicado: (1993)

Respiratory syncytial virus
por: Munoz, Flor M., et al.
Publicado: (2020)

MADS-Box Protein Complex VvAG2, VvSEP3 and VvAGL11 Regulates the Formation of Ovules in Vitis vinifera L. cv. ‘Xiangfei’
por: Wang, Yan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jee1s5rsd3rcq9rgm3hdvkghaa