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ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF-κB pathway

BACKGROUND: Inflammation plays a major role in the pulmonary artery hypertension (PAH) and the acute lung injury (ALI) diseases. The common feature of these complications is the dysfunction of pulmonary microvascular endothelial cells (PMVECs). Fasudil, the only Rho kinase (ROCK) inhibitor used in c...

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Detalles Bibliográficos
Autores principales:	Liu, Huanlong, Pan, Zhenhua, Ma, Xindi, Cui, Junru, Gao, Juan, Miao, Qingfeng, Zhu, Zhongning, Chen, Xueyan, Su, Suwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013060/ https://www.ncbi.nlm.nih.gov/pubmed/35428330 http://dx.doi.org/10.1186/s40360-022-00565-7

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