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Clinical outcomes of limited repair and conservative approaches in older patients with acute type A aortic dissection
BACKGROUND: Surgical indication and the selection of surgical procedures for acute type A aortic dissection in older patients are controversial; therefore, we aimed to examine the surgical outcomes of acute type A aortic dissection in older patients. METHODS: From January 2012 through December 2019,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013093/ https://www.ncbi.nlm.nih.gov/pubmed/35428343 http://dx.doi.org/10.1186/s13019-022-01819-5 |
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author | Maze, Yasumi Tokui, Toshiya Murakami, Masahiko Nakamura, Bun Inoue, Ryosai Hirano, Reina Hirano, Koji |
author_facet | Maze, Yasumi Tokui, Toshiya Murakami, Masahiko Nakamura, Bun Inoue, Ryosai Hirano, Reina Hirano, Koji |
author_sort | Maze, Yasumi |
collection | PubMed |
description | BACKGROUND: Surgical indication and the selection of surgical procedures for acute type A aortic dissection in older patients are controversial; therefore, we aimed to examine the surgical outcomes of acute type A aortic dissection in older patients. METHODS: From January 2012 through December 2019, 174 patients underwent surgical repair for acute type A aortic dissection. We compared the surgical outcomes between the older (≥ 80 years old) and below-80 (≤ 79 years old) age groups. Additionally, we compared the outcomes between the surgical and conservative treatment groups. RESULTS: The primary entry was found in the ascending aorta in 51.6% and 32.8% of the older and below-80 groups, respectively (p = 0.049). Ascending or hemiarch replacement was performed in all older group patients and 57.3% of the below-80 group patients (total arch replacement was performed in the remaining 42.7%; p < 0.001). Hospital mortality rates were similar in both groups. The significant risk factors for hospital mortality were age, preoperative intubation, cardiopulmonary bypass time, and postoperative stroke. The 5-year survival rates were 48.4% ± 10.3% (older group) and 86.7% ± 2.9% (below-80 group; p < 0.001). The rates of freedom from aortic events at 5 years were 86.9% ± 8.7% (older group) and 86.5% ± 3.9% (below-80 group; p = 0.771). The 5-year survival rate of the conservative treatment subgroup was 19.2% ± 8.0% in the older group, which was not significantly different from that of the surgical treatment subgroup (p = 0.103). CONCLUSION: The surgical approach did not achieve a significant survival advantage over conservative treatment and may not always be a reasonable treatment of choice for older patients. |
format | Online Article Text |
id | pubmed-9013093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90130932022-04-17 Clinical outcomes of limited repair and conservative approaches in older patients with acute type A aortic dissection Maze, Yasumi Tokui, Toshiya Murakami, Masahiko Nakamura, Bun Inoue, Ryosai Hirano, Reina Hirano, Koji J Cardiothorac Surg Research Article BACKGROUND: Surgical indication and the selection of surgical procedures for acute type A aortic dissection in older patients are controversial; therefore, we aimed to examine the surgical outcomes of acute type A aortic dissection in older patients. METHODS: From January 2012 through December 2019, 174 patients underwent surgical repair for acute type A aortic dissection. We compared the surgical outcomes between the older (≥ 80 years old) and below-80 (≤ 79 years old) age groups. Additionally, we compared the outcomes between the surgical and conservative treatment groups. RESULTS: The primary entry was found in the ascending aorta in 51.6% and 32.8% of the older and below-80 groups, respectively (p = 0.049). Ascending or hemiarch replacement was performed in all older group patients and 57.3% of the below-80 group patients (total arch replacement was performed in the remaining 42.7%; p < 0.001). Hospital mortality rates were similar in both groups. The significant risk factors for hospital mortality were age, preoperative intubation, cardiopulmonary bypass time, and postoperative stroke. The 5-year survival rates were 48.4% ± 10.3% (older group) and 86.7% ± 2.9% (below-80 group; p < 0.001). The rates of freedom from aortic events at 5 years were 86.9% ± 8.7% (older group) and 86.5% ± 3.9% (below-80 group; p = 0.771). The 5-year survival rate of the conservative treatment subgroup was 19.2% ± 8.0% in the older group, which was not significantly different from that of the surgical treatment subgroup (p = 0.103). CONCLUSION: The surgical approach did not achieve a significant survival advantage over conservative treatment and may not always be a reasonable treatment of choice for older patients. BioMed Central 2022-04-15 /pmc/articles/PMC9013093/ /pubmed/35428343 http://dx.doi.org/10.1186/s13019-022-01819-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Maze, Yasumi Tokui, Toshiya Murakami, Masahiko Nakamura, Bun Inoue, Ryosai Hirano, Reina Hirano, Koji Clinical outcomes of limited repair and conservative approaches in older patients with acute type A aortic dissection |
title | Clinical outcomes of limited repair and conservative approaches in older patients with acute type A aortic dissection |
title_full | Clinical outcomes of limited repair and conservative approaches in older patients with acute type A aortic dissection |
title_fullStr | Clinical outcomes of limited repair and conservative approaches in older patients with acute type A aortic dissection |
title_full_unstemmed | Clinical outcomes of limited repair and conservative approaches in older patients with acute type A aortic dissection |
title_short | Clinical outcomes of limited repair and conservative approaches in older patients with acute type A aortic dissection |
title_sort | clinical outcomes of limited repair and conservative approaches in older patients with acute type a aortic dissection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013093/ https://www.ncbi.nlm.nih.gov/pubmed/35428343 http://dx.doi.org/10.1186/s13019-022-01819-5 |
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