Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy

Mitochondrial cardiomyopathies are fatal diseases, with no effective treatment. Alterations of heart mitochondrial function activate the mitochondrial integrated stress response (ISR(mt)), a transcriptional program affecting cell metabolism, mitochondrial biogenesis, and proteostasis. In humans, mut...

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Detalles Bibliográficos
Autores principales: Sayles, Nicole M., Southwell, Nneka, McAvoy, Kevin, Kim, Kihwan, Pesini, Alba, Anderson, Corey J., Quinzii, Catarina, Cloonan, Suzanne, Kawamata, Hibiki, Manfredi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013208/
https://www.ncbi.nlm.nih.gov/pubmed/35263592
http://dx.doi.org/10.1016/j.celrep.2022.110475

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