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Discovery of anti-infective adipostatins through bioactivity-guided isolation and heterologous expression of a type III polyketide synthase

Antibiotic resistance and emerging viral pandemics have posed an urgent need for new anti-infective drugs. By screening our microbial extract library against the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the notorious ESKAPE pathogens, an active fraction was i...

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Detalles Bibliográficos
Autores principales:	Hou, Lukuan, Li, Ying, Wu, Qihao, Li, Miyang, Older, Ethan A., Tang, Xiaoyu, Nagarkatti, Prakash, Nagarkatti, Mitzi, Liu, Yuan, Li, Lingjun, Fan, Daping, Bugni, Tim S., Shang, Zhuo, Li, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013261/ https://www.ncbi.nlm.nih.gov/pubmed/34022708 http://dx.doi.org/10.1016/j.bioorg.2021.104925

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